Bioprim 400mg/80mg Tablet - Uses, Price, Side Effects
What is bioprim 400mg/80mg tablet used for?
Bioprim 400mg/80mg Tablet is a combination antibiotic containing Sulfamethoxazole and Trimethoprim. It works by inhibiting bacterial folic acid synthesis, effectively treating infections like urinary tract infections, bronchitis, and traveler's diarrhea. It is typically taken twice daily with a full glass of water.
- Generic Name: Sulfamethoxazole + Trimethoprim
- Manufacturer: BIO Ethicals Pharma Limited
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ bioprim 400mg/80mg tablet Uses & Benefits
Urinary tract infections, Acute otitis media, Pneumocystis jirovecii pneumonia, Traveler's diarrhea, Shigellosis, Bronchitis
Off-label uses: Toxoplasmosis, Nocardiosis, Whipple's disease
๐ Drug Information
| Generic Name(s) | Sulfamethoxazole + Trimethoprim |
| Brand Name | Antrima DS |
| Manufacturer | BIO Ethicals Pharma Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Sulfonamide + Folate antagonist |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Sequential inhibition of folate synthesis: Sulfamethoxazole inhibits dihydropteroate synthase; Trimethoprim inhibits dihydrofolate reductase
Mechanism Steps
๐ก How to Take bioprim 400mg/80mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of bioprim 400mg/80mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Photosensitivity
๐จ Serious Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Aplastic anemia
- Agranulocytosis
- Hepatitis
- Interstitial nephritis
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Pancreatitis
- Serum sickness
- Lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Phenytoin | Moderate | Increased phenytoin levels |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Phenytoin
- Sulfonylureas
- Cyclosporine
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Procainamide
- Amantadine
โน๏ธ Minor Interactions
- Oral contraceptives
- Rifampin
๐ฝ๏ธ Food Interactions
Folate-rich foods may reduce efficacy
๐ท Alcohol Interaction
Avoid alcohol; may cause disulfiram-like reaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to sulfonamides or trimethoprim, Severe hepatic or renal impairment, Megaloblastic anemia due to folate deficiency, Pregnancy (especially 1st and 3rd trimester), Infants <2 months
๐ Monitoring Parameters
Renal function, Hepatic function, CBC with differential, Serum potassium, Signs of hypersensitivity
๐คฑ Lactation Safety
Caution; excreted in breast milk; avoid in nursing infants <2 months
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; folate supplementation for trimethoprim toxicity
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose