coldfresh plus tablet - Uses, Price, Side Effects & Substitutes
What is coldfresh plus tablet used for?
Azicold Plus Tablet (Caffeine + Cetirizine) is used to treat RESPIRATORY. It contains Caffeine (30mg) + Cetirizine (5mg), which Cetirizine selectively inhibits peripheral H1 receptors; caffeine antagonizes ad. Always consult your doctor before use. Take as prescribed.
- Generic Name: Caffeine + Cetirizine
- Manufacturer: Smart Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ coldfresh plus tablet Uses & Benefits
Symptomatic relief of allergic rhinitis, urticaria, and common cold symptoms.
Off-label uses: Motion sickness (cetirizine), adjunct in weight loss (caffeine).
๐ Drug Information
| Generic Name(s) | Caffeine + Cetirizine |
| Brand Name | Azicold Plus Tablet |
| Manufacturer | Smart Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + CNS Stimulant |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cetirizine selectively inhibits peripheral H1 receptors; caffeine antagonizes adenosine receptors and inhibits phosphodiesterase.
Mechanism Steps
๐ก How to Take coldfresh plus tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of coldfresh plus tablet
โ Common Side Effects
- Drowsiness
- Dry mouth
- Headache
- Nervousness
- Insomnia
๐จ Serious Side Effects
- Severe allergic reactions
- Tachycardia
- Seizures (caffeine overdose)
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Thrombocytopenia
- Angioedema
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Increased risk of hypertensive crisis |
| CYP1A2 inhibitors | Major | Increased caffeine toxicity |
| Alcohol | Moderate | Enhanced CNS depression |
| Sedatives | Moderate | Additive sedation |
| Anticholinergics | Moderate | Increased anticholinergic effects |
| Theophylline | Minor | Additive CNS stimulation |
| Phenytoin | Minor | Decreased caffeine metabolism |
๐จ Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CYP1A2 inhibitors (e.g., ciprofloxacin)
โก Moderate Interactions
- Alcohol
- Sedatives
- Anticholinergics
โน๏ธ Minor Interactions
- Theophylline
- Phenytoin
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase caffeine levels; food does not significantly affect absorption.
๐ท Alcohol Interaction
Increased sedation and impaired coordination; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cetirizine or caffeine, severe hypertension, arrhythmias, peptic ulcer.
๐ Monitoring Parameters
Monitor for sedation, CNS stimulation, and blood pressure in susceptible patients.
๐คฑ Lactation Safety
Cetirizine and caffeine are excreted in breast milk; use with caution.
๐ Overdose Management
Supportive care; activated charcoal if recent ingestion; monitor for CNS stimulation and cardiac effects.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double dose.