carboplatin 450mg injection - Uses, Price, Side Effects & Substitutes
What is carboplatin 450mg injection used for?
Adcarb 450mg Injection (Carboplatin) is used to treat ANTI NEOPLASTICS. It contains Carboplatin (450mg), which Platinum compound forms DNA cross-links, inhibiting DNA replication and transcri. Always consult your doctor before use. Take as prescribed.
- Generic Name: Carboplatin
- Manufacturer: Pfizer Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ carboplatin 450mg injection Uses & Benefits
Ovarian carcinoma, lung cancer, head and neck cancers, testicular cancer, bladder cancer.
Off-label uses: Endometrial cancer, cervical cancer, osteosarcoma.
๐ Drug Information
| Generic Name(s) | Carboplatin |
| Brand Name | Adcarb 450mg Injection |
| Manufacturer | Pfizer Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Platinum compounds-Anticancer |
| Route of Administration | Intravenous infusion. |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Platinum compound forms DNA cross-links, inhibiting DNA replication and transcription.
Mechanism Steps
๐ก How to Take carboplatin 450mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of carboplatin 450mg injection
โ Common Side Effects
- Nausea
- vomiting
- myelosuppression (thrombocytopenia, neutropenia, anemia)
- fatigue
๐จ Serious Side Effects
- Severe myelosuppression
- nephrotoxicity
- ototoxicity
- hypersensitivity reactions
- hemolytic uremic syndrome
โ ๏ธ Rare Side Effects
- Secondary malignancies
- interstitial pneumonitis
- hepatic veno-occlusive disease
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | Increased nephrotoxicity and ototoxicity |
| Warfarin | Moderate | Increased anticoagulant effect |
| Phenytoin | Moderate | Decreased phenytoin levels |
| Live vaccines | Minor | Risk of disseminated infection |
๐จ Major Interactions
- Nephrotoxic drugs (e.g., aminoglycosides)
- Other myelosuppressive agents
โก Moderate Interactions
- Warfarin
- Phenytoin
โน๏ธ Minor Interactions
- Live vaccines
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol due to increased risk of hepatotoxicity and GI side effects.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Severe renal impairment (CrCl < 20 mL/min), severe myelosuppression, hypersensitivity to platinum compounds, pregnancy.
๐ Monitoring Parameters
Complete blood count (CBC), renal function (serum creatinine, BUN), liver function tests, audiometry.
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care, monitor bone marrow function, consider hematopoietic growth factors.
โฐ Missed Dose
Do not double dose; contact healthcare provider for rescheduling.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for carboplatin 450mg injection
View AllAlternative brands with exact same active ingredient (Carboplatin (450mg)):
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blastoplatin 450mg injectionChandra Bhagat Pharma Pvt Ltd โน1,682.81 39.7% CHEAPER
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karplat 450mg infusionCadila Pharmaceuticals Ltd โน1,952.53 30% CHEAPER
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womaplat 450mg injectionParenteral Drugs India Ltd โน2,083.33 25.3% CHEAPER
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adcarb 450mg injectionAdley Formulations โน2,184.00 21.7% CHEAPER
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naproplat 450mg injectionMiracalus Pharma Pvt Ltd โน2,300.00 17.6% CHEAPER
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lyocarb 450mg injectionUSV Ltd โน2,330.00 16.5% CHEAPER
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celcarb 450mg injectionCelon Laboratories Ltd โน2,333.00 16.4% CHEAPER
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carbotero 450 mg injectionHetero Drugs Ltd โน2,433.00 12.8% CHEAPER
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cytocarb 450mg injectionCipla Ltd โน2,507.08 10.2% CHEAPER
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mediocarb 450mg injectionMedion Biotech Pvt Ltd โน2,517.00 9.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.