capril m 2mg/500mg tablet - Glimepiride (2mg) + Metformin (500mg) medicine

capril m 2mg/500mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Captab Biotec ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is capril m 2mg/500mg tablet used for?

Amaryl M 1mg Tablet PR (Glimepiride + Metformin) is used to treat ANTI DIABETIC. It contains Glimepiride (2mg) + Metformin (500mg), which Glimepiride: Stimulates insulin release from pancreatic beta cells; Metformin: D. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Glimepiride + Metformin
  • Manufacturer: Captab Biotec
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š capril m 2mg/500mg tablet Uses & Benefits

Type 2 diabetes mellitus when diet and exercise alone are inadequate

Off-label uses: Polycystic ovary syndrome (metformin component)

๐Ÿ“‹ Drug Information

Generic Name(s)Glimepiride + Metformin
Brand NameAmaryl M 1mg Tablet PR
ManufacturerCaptab Biotec
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action ClassSulfonylurea + Biguanide
Route of AdministrationOral
StorageStore at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF); protect from moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionGlimepiride: Rapidly and completely absorbed; Metformin: Absorbed mainly from small intestine
DistributionGlimepiride: High protein binding, distributed to breast milk; Metformin: Low protein binding, distributed to erythrocytes
Protein BindingGlimepiride: >99.5%; Metformin: Negligible
MetabolismGlimepiride: Hepatic via CYP2C9; Metformin: Not metabolized
Half-LifeGlimepiride: 5-9 hours; Metformin: 6.2 hours
ExcretionGlimepiride: 60% renal, 40% fecal; Metformin: 90% renal unchanged
BioavailabilityGlimepiride: 100%; Metformin: 50-60%
Onset of ActionGlimepiride: 1 hour; Metformin: 2-3 hours
Peak Plasma TimeGlimepiride: 2-3 hours; Metformin: 2-3 hours
Duration of ActionGlimepiride: 24 hours; Metformin: 8-12 hours

How It Works

Glimepiride: Stimulates insulin release from pancreatic beta cells; Metformin: Decreases hepatic glucose production, increases insulin sensitivity

Mechanism Steps

1Glimepiride binds to SUR1 on pancreatic beta cells
2Closes ATP-sensitive potassium channels
3Depolarizes cell membrane

๐Ÿ’ก How to Take capril m 2mg/500mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of capril m 2mg/500mg tablet

โœ… Common Side Effects

  • Hypoglycemia
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Headache
  • Dizziness

๐Ÿšจ Serious Side Effects

  • Lactic acidosis
  • Severe hypoglycemia
  • Hepatic injury
  • Pancreatitis

โš ๏ธ Rare Side Effects

  • Megaloblastic anemia
  • Photosensitivity
  • Disulfiram-like reaction
  • Cholestatic jaundice

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Insulin Major Increased risk of hypoglycemia
Miconazole Major Enhanced hypoglycemic effect
Alcohol Major Increased risk of lactic acidosis and hypoglycemia
ACE inhibitors Moderate Enhanced hypoglycemic effect
Beta-blockers Moderate Mask hypoglycemia symptoms
Corticosteroids Moderate Hyperglycemia
Diuretics Moderate Hyperglycemia
NSAIDs Moderate Enhanced hypoglycemic effect
Cimetidine Minor Increased metformin levels
Nifedipine Minor Increased metformin absorption

๐Ÿšจ Major Interactions

  • Insulin
  • Other sulfonylureas
  • Miconazole
  • Phenylbutazone
  • Alcohol

โšก Moderate Interactions

  • ACE inhibitors
  • Beta-blockers
  • Clarithromycin
  • Corticosteroids
  • Diuretics
  • NSAIDs

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Ranitidine
  • Nifedipine

๐Ÿฝ๏ธ Food Interactions

Food delays absorption of glimepiride; metformin absorption reduced by food

๐Ÿท Alcohol Interaction

Increased risk of hypoglycemia and lactic acidosis

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Type 1 diabetes, diabetic ketoacidosis, severe renal impairment (eGFR <30), hepatic impairment, hypersensitivity, acute conditions with risk of hypoxia

๐Ÿ“Š Monitoring Parameters

Blood glucose, HbA1c, renal function (serum creatinine, eGFR), hepatic function, signs of lactic acidosis

๐Ÿคฑ Lactation Safety

Contraindicated; glimepiride excreted in milk, metformin excreted in milk

๐Ÿ’Š Overdose Management

Monitor blood glucose; treat hypoglycemia with oral glucose or IV dextrose; for metformin overdose, consider hemodialysis

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

๐Ÿ”— View Profile

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