bibonase nasal spray - Fluticasone Propionate (50mcg) + Azelastine (140mcg) medicine

bibonase nasal spray - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Bibo Pharma ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is bibonase nasal spray used for?

Azeflo Nasal Spray (Fluticasone Propionate + Azelastine) is used to treat RESPIRATORY. It contains Fluticasone Propionate (50mcg) + Azelastine (140mcg), which Fluticasone propionate is a corticosteroid that reduces inflammation by inhibiti. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Fluticasone Propionate + Azelastine
  • Manufacturer: Bibo Pharma
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š bibonase nasal spray Uses & Benefits

Seasonal and perennial allergic rhinitis.

Off-label uses: Non-allergic rhinitis; nasal polyps (fluticasone component).

๐Ÿ“‹ Drug Information

Generic Name(s)Fluticasone Propionate + Azelastine
Brand NameAzeflo Nasal Spray
ManufacturerBibo Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassCorticosteroid + Antihistamine
Route of AdministrationIntranasal
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionSystemic absorption is minimal after intranasal administration; fluticasone propionate has low oral bioavailability due to extensive first-pass metabolism.
DistributionFluticasone propionate is highly lipophilic; volume of distribution is approximately 4.2 L/kg. Azelastine distributes widely with a volume of distribution of about 14.5 L/kg.
Protein BindingFluticasone propionate: 91%; Azelastine: approximately 88%.
MetabolismFluticasone propionate is metabolized via CYP3A4 to inactive metabolites. Azelastine is metabolized by CYP3A4 and CYP2D6 to active metabolite desmethylazelastine.
Half-LifeFluticasone propionate: 7.8 hours; Azelastine: 22 hours.
ExcretionFluticasone propionate: primarily fecal (90%) and urinary (<5%). Azelastine: primarily renal (75%) as metabolites.
BioavailabilityFluticasone propionate: <1% systemic bioavailability after intranasal use. Azelastine: 40% systemic
Onset of ActionWithin 30 minutes for symptom relief.
Peak Plasma TimeFluticasone propionate: 1-2 hours; Azelastine: 2-3 hours.
Duration of ActionUp to 24 hours.

How It Works

Fluticasone propionate is a corticosteroid that reduces inflammation by inhibiting inflammatory mediators. Azelastine is an antihistamine that blocks histamine H1 receptors, reducing allergic symptoms.

Mechanism Steps

1Fluticasone propionate binds to glucocorticoid receptor in nasal mucosa.
2Receptor-ligand complex translocates to nucleus and modulates gene transcription.
3Inhibits pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-alpha).

๐Ÿ’ก How to Take bibonase nasal spray

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of bibonase nasal spray

โœ… Common Side Effects

  • Headache
  • Epistaxis
  • Nasal discomfort
  • Sneezing
  • Bitter taste

๐Ÿšจ Serious Side Effects

  • Nasal ulceration
  • Perforation
  • Glaucoma
  • Cataracts
  • Adrenal suppression

โš ๏ธ Rare Side Effects

  • Anaphylaxis
  • Angioedema
  • Bronchospasm

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Ketoconazole Major Increased fluticasone systemic exposure
Ritonavir Major Increased fluticasone systemic exposure
Rifampin Moderate Decreased fluticasone efficacy
Fluoxetine Moderate Increased azelastine levels
Alcohol Minor Increased sedation

๐Ÿšจ Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
  • Other corticosteroids (systemic)

โšก Moderate Interactions

  • CYP3A4 inducers (e.g., rifampin)
  • CYP2D6 inhibitors (e.g., fluoxetine)

โ„น๏ธ Minor Interactions

  • Alcohol
  • Sedatives

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

May increase sedation risk.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to any component; untreated nasal infection.

๐Ÿ“Š Monitoring Parameters

Nasal symptoms; signs of adrenal suppression with prolonged use.

๐Ÿคฑ Lactation Safety

Caution; limited data, but systemic absorption is low.

๐Ÿ’Š Overdose Management

No specific antidote; supportive care. Acute overdose unlikely due to low systemic absorption.

โฐ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

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