bestoflox n 100 mg/50 mg suspension - Uses, Price, Side Effects & Substitutes
What is bestoflox n 100 mg/50 mg suspension used for?
Annoflox NZ Syrup (Nitazoxanide + Ofloxacin) is used to treat ANTI INFECTIVES. It contains Nitazoxanide (100mg) + Ofloxacin (50mg), which Nitazoxanide: Interferes with pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-d. Always consult your doctor before use. Take as prescribed.
- Generic Name: Nitazoxanide + Ofloxacin
- Manufacturer: BestoChem Formulations India Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ bestoflox n 100 mg/50 mg suspension Uses & Benefits
Infectious diarrhea caused by Giardia lamblia, Cryptosporidium parvum, and susceptible bacteria; mixed infections
Off-label uses: Treatment of amebiasis, cyclosporiasis, and other protozoal infections
๐ Drug Information
| Generic Name(s) | Nitazoxanide + Ofloxacin |
| Brand Name | Annoflox NZ Syrup |
| Manufacturer | BestoChem Formulations India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antidiarrheal, Antiprotozoal, Fluoroquinolone Antibiotic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nitazoxanide: Interferes with pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction, inhibiting anaerobic metabolism; Ofloxacin: Inhibits DNA gyrase and topoisomerase IV, preventing bacterial DNA replication
Mechanism Steps
๐ก How to Take bestoflox n 100 mg/50 mg suspension
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of bestoflox n 100 mg/50 mg suspension
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- Dizziness
- Insomnia
๐จ Serious Side Effects
- Tendonitis/tendon rupture
- Peripheral neuropathy
- CNS effects (seizures, confusion)
- QT prolongation
- Clostridium difficile colitis
- Severe hypersensitivity reactions
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Nephrotoxicity
- Blood dyscrasias
- Photosensitivity
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Antacids (Mg/Al) | Major | Reduced absorption of Ofloxacin |
| Sucralfate | Major | Reduced absorption of Ofloxacin |
| Iron supplements | Major | Reduced absorption of Ofloxacin |
| Zinc supplements | Major | Reduced absorption of Ofloxacin |
| Didanosine | Major | Reduced absorption of Ofloxacin |
| NSAIDs | Major | Increased CNS stimulation and seizure risk |
| Theophylline | Major | Increased theophylline levels and toxicity |
| Corticosteroids | Major | Increased risk of tendon rupture |
| QT-prolonging agents | Major | Increased risk of arrhythmias |
| Cyclosporine | Moderate | Increased nephrotoxicity risk |
| Methotrexate | Moderate | Increased methotrexate levels |
| Phenytoin | Moderate | Altered phenytoin levels |
| Glyburide | Moderate | Increased hypoglycemic effect |
| Insulin | Moderate | Increased hypoglycemic effect |
| Probenecid | Moderate | Increased Ofloxacin levels |
| Cimetidine | Moderate | Increased Ofloxacin levels |
| Caffeine | Minor | Reduced caffeine clearance |
| Dairy products | Minor | Reduced Ofloxacin absorption |
| Calcium supplements | Minor | Reduced Ofloxacin absorption |
๐จ Major Interactions
- Warfarin
- Antacids containing Mg/Al
- Sucralfate
- Iron supplements
- Zinc supplements
- Didanosine
- NSAIDs
- Theophylline
- Corticosteroids
- QT-prolonging agents
โก Moderate Interactions
- Cyclosporine
- Methotrexate
- Phenytoin
- Glyburide
- Insulin
- Probenecid
- Cimetidine
โน๏ธ Minor Interactions
- Caffeine
- Dairy products
- Calcium supplements
๐ฝ๏ธ Food Interactions
Avoid dairy products, calcium-fortified juices, and antacids within 2 hours of dosing; food may delay absorption but not extent
๐ท Alcohol Interaction
Avoid alcohol; may increase CNS effects and hepatotoxicity risk
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to nitazoxanide, ofloxacin, or other fluoroquinolones; history of tendon disorders with fluoroquinolones; children <18 years (except for specific indications); pregnancy (Ofloxacin); lactation
๐ Monitoring Parameters
Renal function, hepatic function, blood glucose (if diabetic), ECG (if at risk of QT prolongation), signs of tendonitis or neuropathy
๐คฑ Lactation Safety
Not recommended; Ofloxacin excreted in breast milk, risk of arthropathy in infants
๐ Overdose Management
Supportive care; activated charcoal may reduce absorption; monitor ECG for QT prolongation
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose