Azipep 4000mg/500mg Injection - Uses, Price, Side Effects
What is azipep 4000mg/500mg injection used for?
Azipep 4000mg/500mg Injection is a combination antibiotic containing Piperacillin (4000mg) and Tazobactam (500mg). Piperacillin is a penicillin-type antibiotic that kills bacteria by inhibiting cell wall synthesis, while Tazobactam is a beta-lactamase inhibitor that prevents bacterial resistance. It is used to treat moderate to severe bacterial infections including pneumonia, intra-abdominal infections, and urinary tract infections. It is administered intravenously under medical supervision.
- Generic Name: Piperacillin + Tazobactam
- Manufacturer: Azilliane Healthcare
- Medicine Form: Allopathy
- Pregnancy Category: B
🇮🇳 azipep 4000mg/500mg injection के बारे में संक्षिप्त जानकारी (Hindi Summary)
azipep 4000mg/500mg injection का उपयोग मुख्य रूप से anti infectives और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Piperacillin (4000mg) + Tazobactum (500mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Drug Information
| Generic Name(s) | Piperacillin + Tazobactam |
|---|---|
| Brand Name | Ahentaz 4.5 Injection |
| Manufacturer | Azilliane Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillin antibiotic with beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion |
| Storage | Store at 20-25°C (68-77°F); reconstituted solution stable for 24 hours at room temperature or 48 hours under refrigeration. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
📅 When to take azipep 4000mg/500mg injection?
💡 How and when to take azipep 4000mg/500mg injection?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at 20-25°C (68-77°F); reconstituted solution stable for 24 hours at room temperature or 48 hours under refrigeration.
⚙️ How azipep 4000mg/500mg injection Works
Piperacillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Tazobactam irreversibly inhibits beta-lactamases, protecting piperacillin from degradation.
💊 azipep 4000mg/500mg injection Uses in Hindi (Ke Fayde), Benefits & Indications
Intra-abdominal infections, urinary tract infections, respiratory tract infections, skin and soft tissue infections, septicemia, febrile neutropenia.
Off-label uses: Bone and joint infections, Endocarditis, Meningitis
⚠️ What are the side effects of azipep 4000mg/500mg injection?
✅ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Headache
- Insomnia
- Rash
🚨 Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile diarrhea
- Acute renal failure
- Hepatitis
⚠️ Rare Side Effects
- Agranulocytosis
- Hemolytic anemia
- Seizures
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Probenecid | Moderate | Reduced renal excretion of piperacillin |
| Vecuronium | Moderate | Prolonged neuromuscular blockade |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Vecuronium
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Cyclosporine
- Tacrolimus
ℹ️ Minor Interactions
- Heparin
- NSAIDs
🍷 Alcohol Interaction
No direct interaction, but alcohol may increase side effects like nausea.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity to penicillins, cephalosporins, or beta-lactamase inhibitors.
📊 Monitoring Parameters
Renal function, hepatic function, CBC, signs of hypersensitivity, bleeding, superinfection.
🤱 Lactation Safety
Excreted in breast milk in low amounts; use with caution.
💊 Overdose Management
Supportive care; hemodialysis may enhance elimination.
⏰ Missed Dose
Administer as soon as possible; do not double dose.
🛑 Myths vs. Facts about azipep 4000mg/500mg injection
- Myth: Generic substitutes of azipep 4000mg/500mg injection are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Piperacillin (4000mg) + Tazobactum (500mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of azipep 4000mg/500mg injection can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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