axytop soap - Ketoconazole (2% w/w) medicine

Axytop Soap (Ketoconazole 2% w/w) - Uses, Price, Side Effects

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๐Ÿญ Axyzen Life Sciences ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 22, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 22, 2026

What is axytop soap used for?

Axytop Soap contains Ketoconazole 2% w/w, an antifungal agent that treats dandruff, seborrheic dermatitis, and fungal skin infections like tinea versicolor and ringworm. It works by disrupting the cell membrane of fungi, killing them and preventing their growth. Use it as a soap substitute on affected areas, leaving on for 3-5 minutes before rinsing.

  • Generic Name: Ketoconazole
  • Manufacturer: Axyzen Life Sciences
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š axytop soap Uses & Benefits

Treatment of seborrheic dermatitis of the scalp; dandruff; tinea versicolor; pityriasis capitis.

Off-label uses: Tinea capitis, Candidal intertrigo, Malassezia folliculitis

๐Ÿ“‹ Drug Information

Generic Name(s)Ketoconazole
Brand NameArcolane 2% Scalp Solution
ManufacturerAxyzen Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassFungal ergosterol synthesis inhibitor
Route of AdministrationTopical (scalp solution)
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and heat.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption when applied topically; less than 1% of dose absorbed through scalp skin.
DistributionDistributes into skin layers, hair follicles, and sebaceous glands; negligible systemic distribution.
Protein BindingApproximately 99% bound to plasma proteins (mainly albumin) if absorbed systemically.
MetabolismHepatic via CYP3A4; extensive first-pass metabolism if absorbed.
Half-LifeTopical: not applicable; systemic: 2-8 hours.
ExcretionPrimarily feces (biliary) and urine (renal) for absorbed fraction.
BioavailabilityNegligible systemic bioavailability (<1%) due to topical application.
Onset of ActionWithin 1-2 weeks of regular use.
Peak Plasma TimeNot applicable for topical use; systemic absorption minimal.
Duration of ActionContinuous use required; effects persist as long as treatment continues.

How It Works

Inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane.

Mechanism Steps

1Ketoconazole binds to fungal CYP51 (lanosterol 14ฮฑ-demethylase).
2Inhibition of CYP51 prevents conversion of lanosterol to ergosterol.
3Depletion of ergosterol disrupts fungal cell membrane integrity.

๐Ÿ’ก How to Take axytop soap

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of axytop soap

โœ… Common Side Effects

  • Scalp irritation
  • Dryness
  • Pruritus
  • Oiliness
  • Hair discoloration
  • Contact dermatitis

๐Ÿšจ Serious Side Effects

  • Severe allergic reaction (angioedema, anaphylaxis)
  • Hepatotoxicity (rare with topical use)

โš ๏ธ Rare Side Effects

  • Bullous dermatitis
  • Urticaria
  • Hair loss

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Moderate May enhance anticoagulant effect
Corticosteroids Minor May reduce antifungal efficacy

๐Ÿšจ Major Interactions

  • Warfarin
  • CYP3A4 substrates (e.g., midazolam, triazolam)
  • Cisapride
  • Pimozide
  • Quinidine
  • Lovastatin
  • Simvastatin

โšก Moderate Interactions

  • Oral hypoglycemics
  • Phenytoin
  • Rifampin
  • Isoniazid
  • Antacids
  • H2 blockers
  • Proton pump inhibitors

โ„น๏ธ Minor Interactions

  • Caffeine
  • Alcohol
  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice (may increase systemic absorption if ingested, but topical use minimal)

๐Ÿท Alcohol Interaction

No significant interaction with topical use; disulfiram-like reaction possible with systemic use but not relevant here.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity to ketoconazole or any component; avoid use on broken or inflamed skin.

๐Ÿ“Š Monitoring Parameters

Clinical improvement of scalp condition; signs of irritation or allergic reaction; liver function tests if prolonged use or systemic absorption suspected.

๐Ÿคฑ Lactation Safety

Likely safe; minimal systemic absorption; caution if applied to breast area.

๐Ÿ’Š Overdose Management

Unlikely with topical use; accidental ingestion: symptomatic and supportive care; gastric lavage if large amount ingested.

โฐ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 22, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for axytop soap

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Alternative brands with exact same active ingredient (Ketoconazole (2% w/w)):

Medical Note: Always consult your doctor before switching medications.

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