Axitrix T 1000mg/125mg Injection - Uses, Price, Side Effects
What is axitrix t 1000mg/125mg injection used for?
Axitrix T 1000mg/125mg Injection is a combination antibiotic containing Ceftriaxone (a cephalosporin) and Tazobactam (a beta-lactamase inhibitor). It is used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and intra-abdominal infections. Ceftriaxone kills bacteria by interfering with cell wall synthesis, while Tazobactam prevents bacterial resistance by inhibiting beta-lactamase enzymes. This injection is administered intravenously or intramuscularly under medical supervision.
- Generic Name: Ceftriaxone + Tazobactam
- Manufacturer: Axis Life Science Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ axitrix t 1000mg/125mg injection Uses & Benefits
Treatment of infections caused by susceptible organisms: respiratory tract, urinary tract, skin and soft tissue, intra-abdominal, septicemia, meningitis.
Off-label uses: Lyme disease, Pelvic inflammatory disease, Gonorrhea
๐ Drug Information
| Generic Name(s) | Ceftriaxone + Tazobactam |
| Brand Name | Accutaz AS |
| Manufacturer | Axis Life Science Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Beta-lactamase inhibitor) |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Storage | Store at 20-25ยฐC; protect from light; reconstituted solution stable for 24 hours at room temperature or 3 days refrigerated. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Tazobactam inhibits beta-lactamases, preventing degradation of ceftriaxone.
Mechanism Steps
๐ก How to Take axitrix t 1000mg/125mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of axitrix t 1000mg/125mg injection
โ Common Side Effects
- Diarrhea
- Injection site pain
- Rash
- Eosinophilia
๐จ Serious Side Effects
- Anaphylaxis
- Clostridioides difficile colitis
- Severe skin reactions (SJS/TEN)
- Hemolytic anemia
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Biliary sludge
- Thrombocytopenia
- Interstitial nephritis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Probenecid | Moderate | Reduced excretion of ceftriaxone |
| Live Typhoid Vaccine | Moderate | Reduced vaccine efficacy |
๐จ Major Interactions
- Warfarin
- Aminoglycosides
- Loop diuretics
- Probenecid
โก Moderate Interactions
- Oral contraceptives
- Live vaccines
- BCG vaccine
โน๏ธ Minor Interactions
- Chloramphenicol
- Tetracyclines
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
May cause disulfiram-like reaction (rare with ceftriaxone)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or beta-lactamase inhibitors; hyperbilirubinemic neonates (ceftriaxone displaces bilirubin).
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of superinfection, bleeding time (if on warfarin).
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; generally considered compatible.
๐ Overdose Management
Supportive care; hemodialysis may remove ceftriaxone but not tazobactam.
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.