avastin 400mg injection - Uses, Price, Side Effects & Substitutes
What is avastin 400mg injection used for?
Avastin (Bevacizumab) is used to treat Metastatic colorectal cancer. It contains Bevacizumab (400mg), which Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its i. Always consult your doctor before use. Take as prescribed.
- Generic Name: Bevacizumab
- Manufacturer: Roche Products India Pvt Ltd
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 avastin 400mg injection के बारे में संक्षिप्त जानकारी (Hindi Summary)
avastin 400mg injection का उपयोग मुख्य रूप से anti neoplastics और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Bevacizumab (400mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
मुख्य फायदे (Key Benefits): Avastin 400mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney can... Read more below.
📋 Drug Information
| Generic Name(s) | Bevacizumab |
|---|---|
| Brand Name | Avastin |
| Manufacturer | Roche Products India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Vascular endothelial growth factor (VEGF) inhibitor |
| Route of Administration | Intravenous infusion. |
| Storage | Store at 2-8°C (36-46°F). Do not freeze. Protect from light. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
💡 How and when to take avastin 400mg injection?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at 2-8°C (36-46°F). Do not freeze. Protect from light.
⚙️ How avastin 400mg injection Works
Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its interaction with VEGF receptors on endothelial cells, thereby inhibiting angiogenesis.
💊 avastin 400mg injection Uses in Hindi (Ke Fayde), Benefits & Indications
Metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, ovarian cancer, cervical cancer.
Off-label uses: Age-related macular degeneration (intravitreal), diabetic retinopathy, other solid tumors.
⚠️ What are the side effects of avastin 400mg injection?
✅ Common Side Effects
- Hypertension
- Fatigue
- Diarrhea
- Nausea
- Headache
- Proteinuria
- Epistaxis
🚨 Serious Side Effects
- Gastrointestinal perforation
- Hemorrhage
- Arterial thromboembolism
- Wound dehiscence
- Congestive heart failure
- Reversible posterior leukoencephalopathy syndrome
⚠️ Rare Side Effects
- Osteonecrosis of the jaw
- Nephrotic syndrome
- Pulmonary hypertension
- Ovarian failure
Consult your doctor if you experience any unusual symptoms.
🔄 Best Substitutes for avastin 400mg injection
View AllAlternative brands with exact same active ingredient and strength (Bevacizumab (400mg)):
- abevmy 400mg injectionMylan Pharmaceuticals Pvt Ltd₹35,120.00💰 70.1% CHEAPER
- krabeva 400mg injectionBiocon₹35,777.44💰 69.6% CHEAPER
- vegfxta 400mg injectionFresenius Kabi India Pvt Ltd₹37,500.00💰 68.1% CHEAPER
- advamab 400 injectionAlkem Laboratories Ltd₹37,998.00💰 67.7% CHEAPER
- bevacirel 400mg injectionReliance Life Sciences₹38,856.34💰 67% CHEAPER
- bevnexxa 400mg injectionCelon Laboratories Ltd₹39,000.00💰 66.8% CHEAPER
- versavo 400 solution for infusionDr Reddy's Laboratories Ltd₹41,994.00💰 64.3% CHEAPER
- cizumab 400 solution for infusionHetero Drugs Ltd₹43,859.00💰 62.7% CHEAPER
- bevarest 400 injectionEmcure Pharmaceuticals Ltd₹43,949.00💰 62.6% CHEAPER
- bevacizab injectionAbbott₹48,990.00💰 58.4% CHEAPER
Medical Note: Always consult your doctor before switching medications. Generic alternatives with same salts are therapeutically equivalent.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Sunitinib | Major | Increased risk of microangiopathic hemolytic anemia |
| Anthracyclines | Major | Increased cardiotoxicity risk |
| Alkylating agents | Major | Increased risk of neutropenia and infections |
| Anticoagulants | Moderate | Increased bleeding risk |
| Antiplatelet agents | Moderate | Increased bleeding risk |
| NSAIDs | Moderate | Increased bleeding risk |
| ACE inhibitors | Minor | Increased risk of proteinuria |
| Diuretics | Minor | Increased risk of electrolyte imbalance |
🚨 Major Interactions
- Sunitinib
- Anthracyclines
- Alkylating agents
⚡ Moderate Interactions
- Anticoagulants
- Antiplatelet agents
- NSAIDs
ℹ️ Minor Interactions
- ACE inhibitors
- Diuretics
🍽️ Food Interactions
No significant food interactions.
🍷 Alcohol Interaction
No known interaction.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity to bevacizumab or any excipients; untreated CNS metastases; recent surgery or wound healing complications; severe bleeding disorders.
📊 Monitoring Parameters
Blood pressure, urine protein, signs of bleeding, wound healing, infusion reactions.
🤱 Lactation Safety
Not recommended; excreted in human milk? Unknown, but potential for harm.
💊 Overdose Management
No specific antidote; manage symptoms and monitor for adverse effects.
⏰ Missed Dose
Administer as soon as possible; do not double dose.
🛑 Myths vs. Facts about avastin 400mg injection
- Myth: Generic substitutes of avastin 400mg injection are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Bevacizumab (400mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of avastin 400mg injection can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
💬 Real Patient Experiences (Astitva)
Join CommunityRead real stories and discussions from our patient community regarding similar health conditions.