Avas 20 D Tablet - Uses, Price, Side Effects
What is avas 20 d tablet used for?
Avas 20 D Tablet is a combination medicine containing Atorvastatin (20mg) and Vitamin D3 (1000IU). Atorvastatin lowers cholesterol and reduces cardiovascular risk by inhibiting HMG-CoA reductase, while Vitamin D3 supports bone health. It is used to manage high cholesterol and prevent heart disease. Take once daily in the evening with or without food.
- Generic Name: Atorvastatin + Vitamin D3
- Manufacturer: Micro Labs Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ avas 20 d tablet Uses & Benefits
Primary hypercholesterolemia, mixed dyslipidemia, homozygous familial hypercholesterolemia, prevention of cardiovascular events, vitamin D deficiency or insufficiency.
Off-label uses: Polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), prevention of contrast-induced nephropathy (atorvastatin), osteoporosis (vitamin D3).
๐ Drug Information
| Generic Name(s) | Atorvastatin + Vitamin D3 |
| Brand Name | Atorsave D 10 Tablet |
| Manufacturer | Micro Labs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | HMG-CoA reductase inhibitor (statin) with vitamin D supplementation |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Atorvastatin competitively inhibits HMG-CoA reductase, reducing cholesterol synthesis; increases LDL receptor expression. Vitamin D3 enhances calcium absorption and bone mineralization.
Mechanism Steps
๐ก How to Take avas 20 d tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of avas 20 d tablet
โ Common Side Effects
- Nasopharyngitis
- Arthralgia
- Diarrhea
- Pain in extremity
- Urinary tract infection
- Dyspepsia
- Nausea
- Musculoskeletal pain
๐จ Serious Side Effects
- Rhabdomyolysis
- Myopathy
- Hepatotoxicity (elevated transaminases, jaundice)
- Hypersensitivity reactions (angioedema, Stevens-Johnson syndrome)
- New-onset diabetes mellitus
- Hemorrhagic stroke (in patients with prior stroke)
โ ๏ธ Rare Side Effects
- Interstitial lung disease
- Peripheral neuropathy
- Memory loss
- Confusion
- Gynecomastia
- Tendon rupture
- Immune-mediated necrotizing myopathy
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Cyclosporine | Moderate | Increased risk of myopathy |
| Erythromycin | Moderate | Increased atorvastatin levels |
| Grapefruit juice | Moderate | Increased atorvastatin levels |
| Digoxin | Minor | Increased digoxin levels |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone)
- Cyclosporine
- Gemfibrozil
- Other fibrates
- Niacin (โฅ1 g/day)
- Colchicine
- Rifampin
- Digoxin
- Oral contraceptives
โก Moderate Interactions
- Warfarin
- Antacids
- Colestipol
- Colesevelam
- Fenofibrate
- Ezetimibe
- Amiodarone
- Verapamil
- Diltiazem
- Grapefruit juice
โน๏ธ Minor Interactions
- Cimetidine
- Ranitidine
- Omeprazole
- Azithromycin
- Fluconazole
๐ฝ๏ธ Food Interactions
Grapefruit juice increases atorvastatin exposure; avoid large quantities. Vitamin D3 absorption enhanced with fatty meals.
๐ท Alcohol Interaction
Excessive alcohol consumption may increase risk of hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Active liver disease, unexplained persistent elevations of serum transaminases, pregnancy, lactation, hypersensitivity to atorvastatin or vitamin D3, concomitant use with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, HIV protease inhibitors).
๐ Monitoring Parameters
Lipid profile (LDL-C, HDL-C, triglycerides), liver function tests (ALT, AST) at baseline and periodically, creatine kinase (CK) if muscle symptoms occur, serum 25-hydroxyvitamin D levels.
๐คฑ Lactation Safety
Atorvastatin is excreted in breast milk; not recommended during breastfeeding. Vitamin D3 is safe.
๐ Overdose Management
No specific antidote; symptomatic and supportive care; monitor liver function and CK levels; consider gastric lavage if recent ingestion.
โฐ Missed Dose
Take missed dose as soon as remembered; if close to next dose, skip missed dose; do not double dose.