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augplat 250mcg injection allopathy (Romiplostim (250mcg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
augplat 250mcg injection allopathy (Romiplostim (250mcg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Zydus Cadila. Contains Romiplostim (250mcg).

augplat 250mcg injection - Uses, Price, Side Effects & Substitutes

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Romiplostim (250mcg) (Click to see all medicines with same salt)
🏭 Zydus Cadila 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is augplat 250mcg injection used for?

Augplat (Romiplostim) is used to treat Chronic immune thrombocytopenia (ITP) in adults; thrombocytopenia in patients with myelodysplastic syndromes (off-label).. It contains Romiplostim (250mcg), which Binds to thrombopoietin (TPO) receptor, activating JAK-STAT and MAPK signaling p. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Romiplostim
  • Manufacturer: Zydus Cadila
  • Medicine Form: Allopathy
  • Pregnancy Category: A

🇮🇳 augplat 250mcg injection के बारे में संक्षिप्त जानकारी (Hindi Summary)

augplat 250mcg injection का उपयोग मुख्य रूप से blood related और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Romiplostim (250mcg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

📋 Drug Information

Generic Name(s)Romiplostim
Brand NameAugplat
ManufacturerZydus Cadila
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassBLOOD RELATED
Action ClassThrombopoietin agonist
Route of AdministrationSubcutaneous injection
StorageStore at 2-8°C (refrigerate); protect from light; do not freeze.
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionSubcutaneous administration; absorption is slow and prolonged.
DistributionDistributed primarily in plasma; limited extravascular distribution.
Protein BindingNot extensively protein-bound; primarily bound to thrombopoietin receptor.
MetabolismMetabolized via catabolism into small peptides and amino acids.
Half-Life1-34 days (mean 3.5 days) due to FcRn-mediated recycling.
ExcretionMinimal renal excretion; primarily eliminated via intracellular catabolism.
BioavailabilityApproximately 82% after subcutaneous injection.
Onset of ActionIncrease in platelet count observed within 1-2 weeks.
Peak Plasma Time7-50 hours (median 14 hours) after subcutaneous dose.
Duration of ActionPlatelet count returns to baseline within 2-3 weeks after discontinuation.

Pharmacodynamics

Mechanism of ActionBinds to thrombopoietin (TPO) receptor, activating JAK-STAT and MAPK signaling pathways, stimulating megakaryocyte proliferation and differentiation.
Target ReceptorThrombopoietin receptor (c-Mpl)
Pharmacodynamic EffectsIncreases platelet production; dose-dependent elevation in platelet count.

💡 How and when to take augplat 250mcg injection?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at 2-8°C (refrigerate); protect from light; do not freeze.

⚙️ How augplat 250mcg injection Works

Binds to thrombopoietin (TPO) receptor, activating JAK-STAT and MAPK signaling pathways, stimulating megakaryocyte proliferation and differentiation.

1 Romiplostim binds to the thrombopoietin (TPO) receptor (c-Mpl) on megakaryocyte progenitor cells.
⬇️
2 Receptor dimerization activates JAK2 and STAT5 signaling pathways.
⬇️
3 Activation of MAPK and PI3K/Akt pathways promotes cell survival and proliferation.
⬇️
4 Increased megakaryocyte differentiation and maturation.
⬇️
5 Enhanced platelet production and release into circulation.

💊 augplat 250mcg injection Uses in Hindi (Ke Fayde), Benefits & Indications

Chronic immune thrombocytopenia (ITP) in adults; thrombocytopenia in patients with myelodysplastic syndromes (off-label).

Off-label uses: Myelodysplastic syndromes, Aplastic anemia, Chemotherapy-induced thrombocytopenia

⚠️ What are the side effects of augplat 250mcg injection?

✅ Common Side Effects

  • Headache
  • Arthralgia
  • Dizziness
  • Insomnia
  • Nausea
  • Fatigue

🚨 Serious Side Effects

  • Thrombosis
  • Bone marrow fibrosis
  • Progression of myelodysplastic syndrome to acute myeloid leukemia

⚠️ Rare Side Effects

  • Allergic reactions
  • Anaphylaxis
  • Rebound thrombocytopenia after discontinuation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug Severity Effect
Warfarin Major Increased bleeding risk due to enhanced platelet count and potential thrombotic events.
Anticoagulants Major Increased bleeding risk.
Antiplatelet agents Major Increased bleeding risk.
Aspirin Moderate Increased bleeding risk.
NSAIDs Moderate Increased bleeding risk.
Heparin Moderate Increased bleeding risk.

🚨 Major Interactions

  • Warfarin
  • Anticoagulants
  • Antiplatelet agents

⚡ Moderate Interactions

  • Aspirin
  • NSAIDs
  • Heparin

ℹ️ Minor Interactions

  • Corticosteroids
  • Immunosuppressants

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction; but caution due to potential bleeding risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to romiplostim or any component; history of thrombotic events.

📊 Monitoring Parameters

Platelet count weekly during titration; then monthly; monitor for thrombotic events.

🤱 Lactation Safety

Not recommended; unknown if excreted in human milk.

💊 Overdose Management

Monitor platelet count; discontinue if platelet count exceeds normal range; supportive care.

⏰ Missed Dose

Administer as soon as remembered; do not double dose; resume regular schedule.

🛑 Myths vs. Facts about augplat 250mcg injection

  • Myth: Generic substitutes of augplat 250mcg injection are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Romiplostim (250mcg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of augplat 250mcg injection can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

💬 Real Patient Experiences (Astitva)

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Read real stories and discussions from our patient community regarding similar health conditions.

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