atracurium besilate injection allopathy (Atracurium (NA)) - Uses in Hindi, Side Effects, Substitutes & Price in India
atracurium besilate injection allopathy (Atracurium (NA)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Sun Pharmaceutical Industries Ltd. Contains Atracurium (NA).

atracurium besilate injection - Uses, Price, Side Effects & Substitutes

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Atracurium (NA) (Click to see all medicines with same salt)
🏭 Sun Pharmaceutical Industries Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is atracurium besilate injection used for?

Atracurium Besilate Injection (Atracurium besilate) is used to treat Adjunct to general anesthesia for skeletal muscle relaxation; facilitation of endotracheal intubation; mechanical ventilation. It contains Atracurium (NA), which Competitive antagonist at nicotinic acetylcholine receptors at the neuromuscular. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Atracurium besilate
  • Manufacturer: Sun Pharmaceutical Industries Ltd
  • Medicine Form: Allopathy
  • Pregnancy Category: C

🇮🇳 atracurium besilate injection के बारे में संक्षिप्त जानकारी (Hindi Summary)

atracurium besilate injection का उपयोग मुख्य रूप से pain analgesics और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Atracurium (NA) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Atracurium Besilate Injection belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provid... Read more below.

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

📋 Drug Information

Generic Name(s)Atracurium besilate
Brand NameAtracurium Besilate Injection
ManufacturerSun Pharmaceutical Industries Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassSkeletal muscle relaxant- Peripherally acting
Route of AdministrationIntravenous (IV)
StorageRefrigerate at 2-8°C; protect from light; do not freeze
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionNot applicable (IV administration)
DistributionWidely distributed; crosses placenta minimally
Protein Binding82%
MetabolismHofmann elimination (non-enzymatic) and ester hydrolysis
Half-Life20 minutes
ExcretionRenal (10-40% unchanged) and biliary
Bioavailability100% (IV)
Onset of Action2-3 minutes
Peak Plasma TimeImmediately after IV bolus
Duration of Action20-35 minutes

Pharmacodynamics

Mechanism of ActionCompetitive antagonist at nicotinic acetylcholine receptors at the neuromuscular junction
Target ReceptorNicotinic acetylcholine receptor (muscle type)
Pharmacodynamic EffectsSkeletal muscle relaxation; no effect on consciousness or pain threshold

💡 How and when to take atracurium besilate injection?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Refrigerate at 2-8°C; protect from light; do not freeze

⚙️ How atracurium besilate injection Works

Competitive antagonist at nicotinic acetylcholine receptors at the neuromuscular junction

1 Atracurium binds competitively to nicotinic acetylcholine receptors at the motor end-plate
⬇️
2 Prevents acetylcholine from binding and depolarizing the muscle membrane
⬇️
3 Inhibits muscle contraction, resulting in skeletal muscle paralysis
⬇️
4 Metabolized via Hofmann elimination (pH- and temperature-dependent) and ester hydrolysis
⬇️
5 Recovery occurs as atracurium dissociates from receptors and is cleared from plasma

💊 atracurium besilate injection Uses in Hindi (Ke Fayde), Benefits & Indications

Adjunct to general anesthesia for skeletal muscle relaxation; facilitation of endotracheal intubation; mechanical ventilation

Off-label uses: Status epilepticus (rarely used)

⚠️ What are the side effects of atracurium besilate injection?

✅ Common Side Effects

  • Hypotension
  • Flushing
  • Bradycardia
  • Skin rash

🚨 Serious Side Effects

  • Anaphylaxis
  • Bronchospasm
  • Prolonged neuromuscular blockade
  • Respiratory depression

⚠️ Rare Side Effects

  • Myopathy
  • Histamine release reactions

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug Severity Effect
Aminoglycosides Major Enhanced neuromuscular blockade
Polymyxins Major Enhanced neuromuscular blockade
Magnesium sulfate Major Enhanced neuromuscular blockade
Lithium Major Enhanced neuromuscular blockade
Quinidine Major Enhanced neuromuscular blockade
Procainamide Major Enhanced neuromuscular blockade
Inhalational anesthetics Moderate Enhanced neuromuscular blockade
Succinylcholine Moderate Enhanced neuromuscular blockade
Calcium channel blockers Moderate Enhanced neuromuscular blockade
Diuretics Moderate Electrolyte imbalance may potentiate blockade
Corticosteroids Minor Possible prolonged blockade
Phenytoin Minor Decreased duration of blockade
Carbamazepine Minor Decreased duration of blockade

🚨 Major Interactions

  • Aminoglycosides
  • Polymyxins
  • Magnesium sulfate
  • Lithium
  • Quinidine
  • Procainamide

⚡ Moderate Interactions

  • Inhalational anesthetics
  • Succinylcholine
  • Calcium channel blockers
  • Diuretics

ℹ️ Minor Interactions

  • Corticosteroids
  • Phenytoin
  • Carbamazepine

🍷 Alcohol Interaction

No specific interaction

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to atracurium or bisbenzylisoquinolinium compounds

📊 Monitoring Parameters

Neuromuscular function (train-of-four monitoring); vital signs; respiratory status

🤱 Lactation Safety

Unknown; use with caution

💊 Overdose Management

Supportive care; neostigmine or other anticholinesterases with atropine to reverse blockade; mechanical ventilation if needed

⏰ Missed Dose

Not applicable (administered by healthcare professional)

🛑 Myths vs. Facts about atracurium besilate injection

  • Myth: Generic substitutes of atracurium besilate injection are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Atracurium (NA)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of atracurium besilate injection can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

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