arzep nasal spray - Azelastine (0.1% w/v) medicine

arzep nasal spray - Uses, Price, Side Effects & Substitutes

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🏭 Zydus Cadila πŸ“¦ Varies by brand πŸ’Š Allopathy πŸ“… Updated: Jun 23, 2026
πŸ“‹ Prescription Required πŸ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is arzep nasal spray used for?

Arzep Nasal Spray (Azelastine) is used to treat RESPIRATORY. It contains Azelastine (0.1% w/v), which Selective histamine H1-receptor antagonist; also inhibits release of inflammator. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Azelastine
  • Manufacturer: Zydus Cadila
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
πŸ’‘ Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

πŸ’Š arzep nasal spray Uses & Benefits

Seasonal and perennial allergic rhinitis.

Off-label uses: Non-allergic rhinitis, Vasomotor rhinitis

πŸ“‹ Drug Information

Generic Name(s)Azelastine
Brand NameArzep Nasal Spray
ManufacturerZydus Cadila
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassH1 Antihistaminics (second Generation)
Route of AdministrationIntranasal
StorageStore at 20-25Β°C (68-77Β°F); protect from light.
Shelf LifeAs per manufacturer

πŸ”¬ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed through nasal mucosa; systemic bioavailability approximately 40% after intranasal administration.
DistributionVolume of distribution approximately 14.5 L/kg; extensively distributed to tissues.
Protein BindingApproximately 88-90% bound to plasma proteins.
MetabolismPrimarily metabolized by CYP3A4 and CYP2D6 to active metabolite desmethylazelastine.
Half-Life22-25 hours for azelastine; 54 hours for desmethylazelastine.
ExcretionApproximately 75% excreted in feces, 25% in urine as metabolites.
BioavailabilityApproximately 40% after intranasal administration.
Onset of ActionWithin 15-30 minutes.
Peak Plasma Time2-3 hours after intranasal administration.
Duration of Action12-24 hours.

How It Works

Selective histamine H1-receptor antagonist; also inhibits release of inflammatory mediators from mast cells.

Mechanism Steps

1Binds to histamine H1 receptors on nasal mucosa.
2Blocks histamine-mediated vasodilation and increased vascular permeability.
3Inhibits release of inflammatory mediators from mast cells.

πŸ’‘ How to Take arzep nasal spray

Follow your doctor's prescription exactly.

⚠️ Side Effects of arzep nasal spray

βœ… Common Side Effects

  • Bitter taste
  • Headache
  • Nasal burning
  • Sneezing
  • Somnolence

🚨 Serious Side Effects

  • Severe allergic reactions
  • Nasal ulceration
  • Epistaxis

⚠️ Rare Side Effects

  • Tachycardia
  • Palpitations
  • Dyspnea

Consult your doctor if you experience any unusual symptoms.

πŸ”¬ Drug Interactions

⚠️ DrugSeverityEffect
Alcohol Major Increased CNS depression and sedation.
Ketoconazole Major Increased azelastine plasma concentration.
Erythromycin Major Increased azelastine plasma concentration.
Cimetidine Moderate Increased azelastine levels.
Ritonavir Moderate Increased azelastine levels.
Clarithromycin Moderate Increased azelastine levels.

🚨 Major Interactions

  • CNS depressants
  • Alcohol
  • Ketoconazole
  • Erythromycin

⚑ Moderate Interactions

  • Cimetidine
  • Ritonavir
  • Clarithromycin

ℹ️ Minor Interactions

  • Anticholinergics
  • Tricyclic antidepressants

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase CNS depression; avoid concurrent use.

πŸ›‘οΈ Safety & Warnings

🚫 Contraindications

Hypersensitivity to azelastine or any component.

πŸ“Š Monitoring Parameters

Assess symptom relief; monitor for sedation.

🀱 Lactation Safety

Excreted in breast milk; use with caution.

πŸ’Š Overdose Management

Symptomatic and supportive care; no specific antidote.

⏰ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose.

πŸ‘¨β€βš•οΈ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

πŸ”— View Profile

πŸ”„ Substitutes for arzep nasal spray

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Alternative brands with exact same active ingredient (Azelastine (0.1% w/v)):

Medical Note: Always consult your doctor before switching medications.

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