ariflu 150mg tablet - Uses, Price, Side Effects & Substitutes
Fluconazole (150mg)
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💊 What is ariflu 150mg tablet used for? (Quick Answer)
AF 150 Tablet DT (Fluconazole) is used to treat Vaginal candidiasis. It contains Fluconazole (150mg), which Inhibits fungal cytochrome P450 14α-demethylase, preventing conversion of lanos. Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Fluconazole
Fluconazole
🏭 Manufacturer
Sarian Healthcare
Sarian Healthcare
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category D
Category D
💡 Pro Tip: Always consult your doctor before starting ariflu 150mg tablet
🇮🇳 ariflu 150mg tablet के बारे में संक्षिप्त जानकारी (Hindi Summary)
ariflu 150mg tablet का उपयोग मुख्य रूप से anti infectives और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Fluconazole (150mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Complete Drug Information for ariflu 150mg tablet
| Generic Name(s) | Fluconazole |
|---|---|
| Brand Name | AF 150 Tablet DT |
| Manufacturer | Sarian Healthcare Verified |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Fungal ergosterol synthesis inhibitor |
| Route of Administration | Oral |
| Storage | Store at 20-25°C (68-77°F); protect from light and moisture |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD) of ariflu 150mg tablet
Pharmacokinetics
AbsorptionWell absorbed after oral administration; bioavailability >90%
DistributionWidely distributed into body tissues and fluids, including CSF
Protein Binding11-12%
MetabolismHepatic metabolism via CYP2C9 and CYP3A4
Half-Life30 hours (range 20-50 hours)
ExcretionPrimarily renal (80% unchanged)
Bioavailability>90%
Onset of ActionRapid; therapeutic levels achieved within 1-2 hours
Peak Plasma Time1-2 hours
Duration of Action24 hours
Pharmacodynamics
Mechanism of ActionInhibits fungal cytochrome P450 14α-demethylase, preventing conversion of lanosterol to ergosterol, disrupting fungal cell membrane synthesis
Target ReceptorFungal CYP51 (lanosterol 14α-demethylase)
Pharmacodynamic EffectsFungistatic activity against Candida spp., Cryptococcus neoformans, and other fungi
💡 How and when to take ariflu 150mg tablet?
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at 20-25°C (68-77°F); protect from light and moisture
⚙️ How ariflu 150mg tablet Works
Inhibits fungal cytochrome P450 14α-demethylase, preventing conversion of lanosterol to ergosterol, disrupting fungal cell membrane synthesis
1
Fluconazole enters fungal cell via diffusion
⬇️
2
Binds to fungal cytochrome P450 14α-demethylase (CYP51)
⬇️
3
Inhibits demethylation of lanosterol to ergosterol
⬇️
4
Depletes ergosterol in fungal cell membrane
⬇️
5
Accumulates toxic 14α-methyl sterols
⬇️
6
Disrupts membrane integrity and function
⬇️
7
Leads to fungal cell growth inhibition and death
💊 ariflu 150mg tablet Uses in Hindi (Ke Fayde), Benefits & Indications
Vaginal candidiasis, oropharyngeal candidiasis, esophageal candidiasis, systemic candidiasis, cryptococcal meningitis, prophylaxis in immunocompromised patients
Off-label uses: Coccidioidomycosis, histoplasmosis, blastomycosis, dermatophytosis, onychomycosis
⚠️ What are the side effects of ariflu 150mg tablet?
✅ Common Side Effects
- Headache
- Nausea
- Abdominal pain
- Diarrhea
- Dizziness
- Rash
🚨 Serious Side Effects
- Hepatotoxicity
- QT prolongation
- Torsades de pointes
- Stevens-Johnson syndrome
- Anaphylaxis
- Exfoliative dermatitis
⚠️ Rare Side Effects
- Alopecia
- Seizures
- Thrombocytopenia
- Leukopenia
- Agranulocytosis
- Hypertriglyceridemia
- Hypokalemia
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions of ariflu 150mg tablet
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Phenytoin | Major | Increased phenytoin levels, toxicity |
| Sulfonylureas | Major | Hypoglycemia |
| Cisapride | Major | QT prolongation, arrhythmias |
| Terfenadine | Major | QT prolongation, arrhythmias |
| Astemizole | Major | QT prolongation, arrhythmias |
| Rifampin | Major | Decreased fluconazole efficacy |
| Rifabutin | Major | Increased rifabutin levels, uveitis |
| Tacrolimus | Major | Increased tacrolimus levels, nephrotoxicity |
| Sirolimus | Major | Increased sirolimus levels |
| Alfentanil | Major | Increased alfentanil levels, respiratory depression |
| Midazolam | Major | Increased midazolam levels, sedation |
| Triazolam | Major | Increased triazolam levels, sedation |
| Nifedipine | Major | Increased nifedipine levels, hypotension |
| Verapamil | Major | Increased verapamil levels, bradycardia |
| Atorvastatin | Major | Increased statin levels, myopathy |
| Simvastatin | Major | Increased statin levels, myopathy |
| Losartan | Major | Decreased losartan efficacy |
| Methadone | Major | Increased methadone levels, QT prolongation |
| Celecoxib | Major | Increased celecoxib levels |
| Flurbiprofen | Major | Increased flurbiprofen levels |
| Naproxen | Major | Increased naproxen levels |
| Ibuprofen | Major | Increased ibuprofen levels |
| Oral contraceptives | Major | Decreased contraceptive efficacy |
| Pimozide | Major | QT prolongation, arrhythmias |
| Quinidine | Major | QT prolongation, arrhythmias |
| Tolbutamide | Major | Hypoglycemia |
| Zidovudine | Major | Increased zidovudine levels |
| Cyclosporine | Moderate | Increased cyclosporine levels |
| Theophylline | Moderate | Increased theophylline levels, toxicity |
| Hydrochlorothiazide | Moderate | Increased fluconazole levels |
| Cimetidine | Minor | Decreased fluconazole absorption |
| Antacids | Minor | Decreased fluconazole absorption |
| Sucralfate | Minor | Decreased fluconazole absorption |
| Didanosine | Minor | Decreased fluconazole absorption |
| Ritonavir | Minor | Increased fluconazole levels |
| Saquinavir | Minor | Increased saquinavir levels |
🚨 Major Interactions
- Warfarin
- Phenytoin
- Sulfonylureas
- Cisapride
- Terfenadine
- Astemizole
- Rifampin
- Rifabutin
- Tacrolimus
- Sirolimus
- Alfentanil
- Benzodiazepines (midazolam, triazolam)
- Calcium channel blockers (nifedipine, verapamil)
- HMG-CoA reductase inhibitors (atorvastatin, simvastatin)
- Losartan
- Methadone
- NSAIDs (celecoxib, flurbiprofen, naproxen, ibuprofen)
- Oral contraceptives
- Pimozide
- Quinidine
- Tolbutamide
- Warfarin
- Zidovudine
⚡ Moderate Interactions
- Cyclosporine
- Theophylline
- Hydrochlorothiazide
- Phenytoin
- Rifampin
- Rifabutin
- Tacrolimus
- Sirolimus
- Alfentanil
- Benzodiazepines (midazolam, triazolam)
- Calcium channel blockers (nifedipine, verapamil)
- HMG-CoA reductase inhibitors (atorvastatin, simvastatin)
- Losartan
- Methadone
- NSAIDs (celecoxib, flurbiprofen, naproxen, ibuprofen)
- Oral contraceptives
- Pimozide
- Quinidine
- Tolbutamide
- Warfarin
- Zidovudine
ℹ️ Minor Interactions
- Cimetidine
- Antacids
- Sucralfate
- Didanosine
- Ritonavir
- Saquinavir
- Zidovudine
🍽️ Food Interactions
No significant food interactions; absorption not affected by food
🍷 Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk
🛡️ Safety & Warnings for ariflu 150mg tablet
🚫 Contraindications
Hypersensitivity to fluconazole or azoles; concomitant use with terfenadine, astemizole, cisapride, pimozide, quinidine
📊 Monitoring Parameters
Liver function tests, renal function, signs of hepatotoxicity, QT interval if risk factors
🤱 Lactation Safety
Excreted in breast milk; use with caution
💊 Overdose Management
Symptomatic and supportive; hemodialysis may enhance elimination
⏰ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.
🛑 Myths vs. Facts about ariflu 150mg tablet
- Myth: Generic substitutes of ariflu 150mg tablet are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Fluconazole (150mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of ariflu 150mg tablet can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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