arfast mr 100mg/325mg/250mg tablet - Uses, Price, Side Effects & Substitutes
What is arfast mr 100mg/325mg/250mg tablet used for?
Aldigesic P (Aceclofenac + Paracetamol) is used to treat PAIN ANALGESICS. It contains Aceclofenac (100mg) + Paracetamol (325mg), which Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paraceta. Always consult your doctor before use. Take as prescribed.
- Generic Name: Aceclofenac + Paracetamol
- Manufacturer: Uvkan Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ arfast mr 100mg/325mg/250mg tablet Uses & Benefits
Pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, dysmenorrhea, fever.
Off-label uses: Postoperative pain, migraine (limited evidence).
๐ Drug Information
| Generic Name(s) | Aceclofenac + Paracetamol |
| Brand Name | Aldigesic P |
| Manufacturer | Uvkan Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, elevating pain threshold and acting on hypothalamic heat-regulating center.
Mechanism Steps
๐ก How to Take arfast mr 100mg/325mg/250mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of arfast mr 100mg/325mg/250mg tablet
โ Common Side Effects
- Nausea
- Dizziness
- Drowsiness
- Rash
- GI upset
๐จ Serious Side Effects
- GI bleeding
- Hepatotoxicity
- Renal failure
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Anaphylaxis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels |
| Aspirin | Major | Increased risk of GI ulceration |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic efficacy |
| Anticoagulants | Moderate | Increased INR |
| SSRIs | Moderate | Increased bleeding risk |
| Antacids | Minor | Reduced absorption of aceclofenac |
| Cholestyramine | Minor | Reduced absorption of paracetamol |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- SSRIs
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid alcohol.
๐ท Alcohol Interaction
Increased risk of hepatotoxicity (paracetamol) and GI bleeding (aceclofenac).
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, history of asthma with NSAIDs.
๐ Monitoring Parameters
Liver function tests, renal function, CBC, blood pressure.
๐คฑ Lactation Safety
Caution; paracetamol is safe, aceclofenac may be excreted in small amounts.
๐ Overdose Management
Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care for aceclofenac.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose.