arbitel-trio 50 tablet er - Uses, Price, Side Effects & Substitutes
What is arbitel-trio 50 tablet er used for?
Arbitel-Trio 50 Tablet ER (Cilnidipine + Metoprolol Succinate) is used to treat Hypertension. It contains Cilnidipine (10mg) + Metoprolol Succinate (50mg), which Cilnidipine: Blocks L-type and N-type calcium channels, reducing calcium influx . Always consult your doctor before use. Take as prescribed.
- Generic Name: Cilnidipine + Metoprolol Succinate
- Manufacturer: Micro Labs Ltd
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 arbitel-trio 50 tablet er के बारे में संक्षिप्त जानकारी (Hindi Summary)
arbitel-trio 50 tablet er का उपयोग मुख्य रूप से cardiac और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Cilnidipine (10mg) + Metoprolol Succinate (50mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Drug Information
| Generic Name(s) | Cilnidipine + Metoprolol Succinate |
|---|---|
| Brand Name | Arbitel-Trio 50 Tablet ER |
| Manufacturer | Micro Labs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + Beta-blocker) |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from light and moisture |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
💡 How and when to take arbitel-trio 50 tablet er?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at room temperature (20-25°C), protect from light and moisture
⚙️ How arbitel-trio 50 tablet er Works
Cilnidipine: Blocks L-type and N-type calcium channels, reducing calcium influx in vascular smooth muscle and sympathetic nerve endings; Metoprolol: Selective beta-1 blocker, reduces heart rate and contractility
💊 arbitel-trio 50 tablet er Uses in Hindi (Ke Fayde), Benefits & Indications
Off-label uses: Angina, arrhythmias (metoprolol component)
⚠️ What are the side effects of arbitel-trio 50 tablet er?
✅ Common Side Effects
- Dizziness
- Fatigue
- Headache
- Edema
- Bradycardia
- Nausea
🚨 Serious Side Effects
- Heart block
- Severe bradycardia
- Hypotension
- Bronchospasm
- Heart failure exacerbation
⚠️ Rare Side Effects
- Thrombocytopenia
- Hepatitis
- Stevens-Johnson syndrome
- Lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | Increased risk of bradycardia and heart block |
| Diltiazem | Major | Additive negative chronotropic effects |
| Clonidine | Major | Rebound hypertension on withdrawal |
| Digoxin | Major | Increased digoxin levels and bradycardia |
| Amiodarone | Major | Increased risk of bradycardia and QT prolongation |
| Ketoconazole | Moderate | Increased cilnidipine levels |
| Fluoxetine | Moderate | Increased metoprolol levels |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Antidiabetic agents | Moderate | Masking of hypoglycemia symptoms |
| Cimetidine | Minor | Slight increase in metoprolol levels |
| Rifampin | Minor | Decreased cilnidipine levels |
🚨 Major Interactions
- Verapamil
- Diltiazem
- Clonidine
- Digoxin
- Amiodarone
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., fluoxetine)
- NSAIDs
- Antidiabetic agents
ℹ️ Minor Interactions
- Cimetidine
- Rifampin
- Alcohol
🍽️ Food Interactions
Avoid grapefruit juice (increases cilnidipine levels); take with or without food
🍷 Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol
🛡️ Safety & Warnings
🚫 Contraindications
Sinus bradycardia, heart block (2nd/3rd degree), cardiogenic shock, decompensated heart failure, sick sinus syndrome, severe hypotension, hypersensitivity
📊 Monitoring Parameters
Blood pressure, heart rate, ECG, blood glucose (in diabetics)
🤱 Lactation Safety
Cilnidipine: Not recommended; Metoprolol: Excreted in milk, use with caution
💊 Overdose Management
Supportive care: atropine for bradycardia, vasopressors for hypotension, calcium gluconate for calcium channel blocker overdose
⏰ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose
🛑 Myths vs. Facts about arbitel-trio 50 tablet er
- Myth: Generic substitutes of arbitel-trio 50 tablet er are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Cilnidipine (10mg) + Metoprolol Succinate (50mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of arbitel-trio 50 tablet er can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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