arava 10mg tablet - Leflunomide (10mg) medicine

arava 10mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Sanofi India Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 23, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is arava 10mg tablet used for?

Arava (Leflunomide) is used to treat PAIN ANALGESICS. It contains Leflunomide (10mg), which Inhibits dihydroorotate dehydrogenase, reducing pyrimidine synthesis and T-cell . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Leflunomide
  • Manufacturer: Sanofi India Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š arava 10mg tablet Uses & Benefits

Rheumatoid arthritis, psoriatic arthritis.

Off-label uses: Juvenile idiopathic arthritis, lupus nephritis.

๐Ÿ“‹ Drug Information

Generic Name(s)Leflunomide
Brand NameArava
ManufacturerSanofi India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassDisease Modifying Anti-Rheumatoid Drugs (DMARDs)- Non biologics
Route of AdministrationOral.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; absorption not affected by food.
DistributionExtensively distributed; crosses placenta and enters breast milk.
Protein Binding>99% bound to albumin.
MetabolismHepatic; converted to active metabolite teriflunomide.
Half-LifeApproximately 2 weeks (teriflunomide).
ExcretionRenal (43%) and fecal (48%) as metabolites.
BioavailabilityApproximately 80%.
Onset of Action4-6 weeks.
Peak Plasma Time6-12 hours (teriflunomide).
Duration of ActionLong; effects persist after discontinuation.

How It Works

Inhibits dihydroorotate dehydrogenase, reducing pyrimidine synthesis and T-cell proliferation.

Mechanism Steps

1Inhibition of dihydroorotate dehydrogenase (DHODH)
2Reduction of de novo pyrimidine synthesis
3Decreased proliferation of activated T lymphocytes

๐Ÿ’ก How to Take arava 10mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of arava 10mg tablet

โœ… Common Side Effects

  • Diarrhea
  • Nausea
  • Headache
  • Alopecia
  • Rash

๐Ÿšจ Serious Side Effects

  • Hepatotoxicity
  • Interstitial lung disease
  • Severe infections
  • Peripheral neuropathy

โš ๏ธ Rare Side Effects

  • Stevens-Johnson syndrome
  • Pancreatitis
  • Agranulocytosis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Methotrexate Major Increased hepatotoxicity
Rifampin Major Increased leflunomide levels
Cholestyramine Major Accelerates elimination
Warfarin Major Increased INR
NSAIDs Moderate Increased GI toxicity
Repaglinide Moderate Increased hypoglycemia risk
Phenytoin Moderate Increased phenytoin levels

๐Ÿšจ Major Interactions

  • Methotrexate
  • Rifampin
  • Cholestyramine
  • Warfarin

โšก Moderate Interactions

  • NSAIDs
  • Oral hypoglycemics
  • Repaglinide
  • Phenytoin

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Omeprazole

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

May increase hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Pregnancy, lactation, severe hepatic impairment, hypersensitivity.

๐Ÿ“Š Monitoring Parameters

Liver function tests, blood pressure, complete blood count.

๐Ÿคฑ Lactation Safety

Contraindicated; excreted in breast milk.

๐Ÿ’Š Overdose Management

Cholestyramine or activated charcoal to accelerate elimination.

โฐ Missed Dose

Take as soon as remembered; skip if near next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for arava 10mg tablet

View All

Alternative brands with exact same active ingredient (Leflunomide (10mg)):

Medical Note: Always consult your doctor before switching medications.

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