Apkos-D Tablet - Uses, Price, Side Effects, and Dosage
What is apkos-d tablet used for?
Apkos-D Tablet is a combination medicine containing Domperidone (10mg) and Pantoprazole (40mg). It is used to treat acidity, heartburn, and gastroesophageal reflux disease (GERD). Pantoprazole reduces stomach acid production, while Domperidone helps control nausea and improves gastric motility. It is typically taken before meals.
- Generic Name: Domperidone + Pantoprazole
- Manufacturer: Apikos Pharma
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 apkos-d tablet के बारे में संक्षिप्त जानकारी (Hindi Summary)
apkos-d tablet का उपयोग मुख्य रूप से gastro intestinal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Domperidone (10mg) + Pantoprazole (40mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.
📋 Drug Information
| Generic Name(s) | Domperidone + Pantoprazole |
|---|---|
| Brand Name | Anleo-DSR Capsule |
| Manufacturer | Apikos Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from moisture and light. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
📅 When to take apkos-d tablet?
💡 How and when to take apkos-d tablet?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at room temperature (20-25°C), protect from moisture and light.
⚙️ How apkos-d tablet Works
Domperidone is a dopamine D2 receptor antagonist that enhances gastric motility and accelerates gastric emptying. Pantoprazole is a proton pump inhibitor that irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion.
💊 apkos-d tablet Uses in Hindi (Ke Fayde), Benefits & Indications
Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, peptic ulcer disease, Zollinger-Ellison syndrome (pantoprazole component).
Off-label uses: Domperidone: Lactation stimulation (not approved in many countries); Pantoprazole: Prevention of stress ulcers, eosinophilic esophagitis.
⚠️ What are the side effects of apkos-d tablet?
✅ Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Flatulence
- Dry mouth
- Dizziness
🚨 Serious Side Effects
- QT prolongation
- Ventricular arrhythmias
- Extrapyramidal symptoms (domperidone)
- Clostridium difficile infection
- Bone fracture (long-term)
- Hypomagnesemia
- Interstitial nephritis
⚠️ Rare Side Effects
- Gynecomastia
- Galactorrhea
- Jaundice
- Hepatitis
- Anaphylaxis
- Stevens-Johnson syndrome
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
🔄 Best Substitutes for apkos-d tablet
View AllAlternative medicines with exact same composition and strength (Domperidone (10mg) + Pantoprazole (40mg)):
- panon d 10 mg/40 mg tabletAngeas Healthcare Ltd₹8.18💰 86.4% CHEAPER
- pantagut dm tabletSymbiotic Drugs₹10.00💰 83.3% CHEAPER
- dpz tabletChicky Pharma Pvt Ltd₹13.21💰 78% CHEAPER
- pantapil d 10mg/40mg tabletPsychotropics India Ltd₹13.27💰 77.9% CHEAPER
- pentagon d 10mg/40mg capsuleInd Swift Laboratories Ltd₹17.18💰 71.4% CHEAPER
- davaindia domperidone+pantoprazole 10mg/40mg tabletDavaindia Generic Pharmacy₹18.00💰 70% CHEAPER
- pantoride-dm tabletZeelab Pharmacy Pvt Ltd₹18.00💰 70% CHEAPER
- drpan d tabletDR Best pharmaceuticals Pvt Ltd₹20.00💰 66.7% CHEAPER
- pankop dsr capsuleKopran Ltd₹25.97💰 56.7% CHEAPER
- StayHappi Domperidone+Pantoprazole 10mg/40mg TabletSarvagunaushdhi Pvt Ltd₹27.00💰 55% CHEAPER
Medical Note: Always consult your doctor before switching medications. Generic alternatives with same salts are therapeutically equivalent.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Moderate | Increased risk of QT prolongation |
| Warfarin | Moderate | Altered anticoagulant effect |
| Methotrexate | Moderate | Increased methotrexate toxicity |
🚨 Major Interactions
- Ketoconazole
- Itraconazole
- Voriconazole
- Clarithromycin
- Erythromycin
- Ritonavir
- Saquinavir
- Amiodarone
- Quinidine
- Methotrexate
⚡ Moderate Interactions
- Warfarin
- Cilostazol
- Citalopram
- Escitalopram
- Fluoxetine
- Paroxetine
- Sertraline
- Tacrolimus
- Cyclosporine
- Digoxin
ℹ️ Minor Interactions
- Sucralfate
- Antacids
- Iron supplements
- Calcium carbonate
🍽️ Food Interactions
Food delays absorption of domperidone; pantoprazole should be taken before meals for optimal effect.
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity to any component; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole) causing QT prolongation; severe hepatic impairment.
📊 Monitoring Parameters
Liver function tests, ECG (QT interval), serum electrolytes, magnesium levels (long-term use), renal function.
🤱 Lactation Safety
Domperidone is excreted in breast milk; pantoprazole is excreted in small amounts. Caution advised.
💊 Overdose Management
Supportive care; domperidone overdose may cause extrapyramidal symptoms; pantoprazole overdose unlikely to cause serious effects.
⏰ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.
🛑 Myths vs. Facts about apkos-d tablet
- Myth: Generic substitutes of apkos-d tablet are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Domperidone (10mg) + Pantoprazole (40mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of apkos-d tablet can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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