Apazine Plus Tablet - Uses, Price, Side Effects
What is apazine plus tablet used for?
Apazine Plus Tablet is a combination medicine containing Aceclofenac (100mg) and Paracetamol (325mg). It is used to relieve pain and inflammation in conditions like arthritis, muscle pain, dental pain, and fever. Aceclofenac works by blocking the production of prostaglandins, while Paracetamol acts on the brain to reduce fever and pain.
- Generic Name: Aceclofenac + Paracetamol
- Manufacturer: Biotic Healthcare
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 apazine plus tablet के बारे में संक्षिप्त जानकारी (Hindi Summary)
apazine plus tablet का उपयोग मुख्य रूप से pain analgesics और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Aceclofenac (100mg) + Paracetamol (325mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Drug Information
| Generic Name(s) | Aceclofenac + Paracetamol |
|---|---|
| Brand Name | Aldigesic P |
| Manufacturer | Biotic Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from moisture. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
📅 When to take apazine plus tablet?
💡 How and when to take apazine plus tablet?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at room temperature (20-25°C), protect from moisture.
⚙️ How apazine plus tablet Works
Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, elevating pain threshold and acting on hypothalamic heat-regulating center.
💊 apazine plus tablet Uses in Hindi (Ke Fayde), Benefits & Indications
Pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, dysmenorrhea, fever.
Off-label uses: Postoperative pain, migraine (limited evidence).
⚠️ What are the side effects of apazine plus tablet?
✅ Common Side Effects
- Nausea
- Dizziness
- Drowsiness
- Rash
- GI upset
🚨 Serious Side Effects
- GI bleeding
- Hepatotoxicity
- Renal failure
- Stevens-Johnson syndrome
⚠️ Rare Side Effects
- Blood dyscrasias
- Anaphylaxis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Aspirin | Moderate | Increased risk of gastrointestinal bleeding |
| Lithium | Moderate | Increased lithium levels |
| ACE inhibitors | Minor | Reduced antihypertensive effect |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- SSRIs
ℹ️ Minor Interactions
- Antacids
- Cholestyramine
🍽️ Food Interactions
Food may delay absorption; avoid alcohol.
🍷 Alcohol Interaction
Increased risk of hepatotoxicity (paracetamol) and GI bleeding (aceclofenac).
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, history of asthma with NSAIDs.
📊 Monitoring Parameters
Liver function tests, renal function, CBC, blood pressure.
🤱 Lactation Safety
Caution; paracetamol is safe, aceclofenac may be excreted in small amounts.
💊 Overdose Management
Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care for aceclofenac.
⏰ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose.
🛑 Myths vs. Facts about apazine plus tablet
- Myth: Generic substitutes of apazine plus tablet are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Aceclofenac (100mg) + Paracetamol (325mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of apazine plus tablet can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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