antop-lsr capsule allopathy (Levosulpiride (75mg) + Pantoprazole (40mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
antop-lsr capsule allopathy (Levosulpiride (75mg) + Pantoprazole (40mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Rhophic Health Care. Contains Levosulpiride (75mg) + Pantoprazole (40mg).

antop-lsr capsule - Uses, Price, Side Effects & Substitutes

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🏭 Rhophic Health Care 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is antop-lsr capsule used for?

Aciban L 75 mg/40 mg Capsule (Levosulpiride + Pantoprazole) is used to treat Gastroesophageal reflux disease (GERD). It contains Levosulpiride (75mg) + Pantoprazole (40mg), which Levosulpiride: Blocks dopamine D2 receptors in GI tract, enhancing motility; Pan. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Levosulpiride + Pantoprazole
  • Manufacturer: Rhophic Health Care
  • Medicine Form: Allopathy
  • Pregnancy Category: A

🇮🇳 antop-lsr capsule के बारे में संक्षिप्त जानकारी (Hindi Summary)

antop-lsr capsule का उपयोग मुख्य रूप से gastro intestinal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Levosulpiride (75mg) + Pantoprazole (40mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

📋 Drug Information

Generic Name(s)Levosulpiride + Pantoprazole
Brand NameAciban L 75 mg/40 mg Capsule
ManufacturerRhophic Health Care
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionLevosulpiride: Rapidly absorbed from GI tract; Pantoprazole: Rapidly absorbed, delayed by food
DistributionLevosulpiride: Widely distributed; Pantoprazole: Volume of distribution ~0.15 L/kg
Protein BindingLevosulpiride: ~40%; Pantoprazole: ~98%
MetabolismLevosulpiride: Minimally metabolized; Pantoprazole: Hepatic via CYP2C19 and CYP3A4
Half-LifeLevosulpiride: ~6-8 hours; Pantoprazole: ~1 hour
ExcretionLevosulpiride: Renal (unchanged); Pantoprazole: Renal (metabolites)
BioavailabilityLevosulpiride: ~30%; Pantoprazole: ~77%
Onset of ActionLevosulpiride: 30-60 min; Pantoprazole: 2-4 hours
Peak Plasma TimeLevosulpiride: 1-3 hours; Pantoprazole: 2-3 hours
Duration of ActionLevosulpiride: 8-12 hours; Pantoprazole: 24 hours

Pharmacodynamics

Mechanism of ActionLevosulpiride: Blocks dopamine D2 receptors in GI tract, enhancing motility; Pantoprazole: Irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing acid secretion
Target ReceptorLevosulpiride: D2 dopamine receptor; Pantoprazole: H+/K+ ATPase (proton pump)
Pharmacodynamic EffectsIncreased gastric emptying and lower esophageal sphincter tone; Reduced gastric acid secretion

💡 How and when to take antop-lsr capsule?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at room temperature (20-25°C), protect from moisture

⚙️ How antop-lsr capsule Works

Levosulpiride: Blocks dopamine D2 receptors in GI tract, enhancing motility; Pantoprazole: Irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing acid secretion

1 Levosulpiride blocks D2 receptors in the GI tract, increasing acetylcholine release and enhancing motility.
⬇️
2 Pantoprazole accumulates in the acidic canaliculi of parietal cells.
⬇️
3 Pantoprazole is activated by acid to form a sulfenamide.
⬇️
4 The sulfenamide binds covalently to H+/K+ ATPase, irreversibly inhibiting proton pump.
⬇️
5 Gastric acid secretion is suppressed for up to 24 hours.

💊 antop-lsr capsule Uses in Hindi (Ke Fayde), Benefits & Indications

Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis

Off-label uses: Functional dyspepsia, diabetic gastroparesis

⚠️ What are the side effects of antop-lsr capsule?

✅ Common Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Dizziness

🚨 Serious Side Effects

  • QT prolongation
  • Tardive dyskinesia
  • Clostridium difficile infection
  • Bone fracture

⚠️ Rare Side Effects

  • Gynecomastia
  • Galactorrhea
  • Interstitial nephritis
  • Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

🔄 Best Substitutes for antop-lsr capsule

View All

Alternative medicines with exact same composition and strength (Levosulpiride (75mg) + Pantoprazole (40mg)):

  1. gonta l 75mg/40mg capsule sr
    Vervetic Healthcare Pvt Ltd₹16.90💰 89.9% CHEAPER
  2. davaindia levosulpiride+pantoprazole 75mg/40mg capsule sr
    Davaindia Generic Pharmacy₹40.00💰 76.2% CHEAPER
  3. pantoride-ls capsule sr
    Zeelab Pharmacy Pvt Ltd₹50.00💰 70.2% CHEAPER
  4. stayhappi levosulpiride+pantoprazole 75mg/40mg capsule
    Sarvagunaushdhi Pvt Ltd₹70.00💰 58.3% CHEAPER
  5. pantoross-l capsule sr
    Emami Frank Ross Ltd₹84.00💰 49.9% CHEAPER
  6. Repen LS 75mg/40mg Capsule
    Lemford Biotech Pvt Ltd₹84.00💰 49.9% CHEAPER
  7. panido l capsule sr
    Shine Pharmaceuticals Ltd₹85.55💰 49% CHEAPER
  8. gutpraz l 75mg/40mg capsule sr
    Macwell Pharmaceuticals₹88.00💰 47.6% CHEAPER
  9. ulcidoc ls 75mg/40mg capsule
    Doctris Lifesciences₹89.00💰 47% CHEAPER
  10. zolpan ls 75mg/40mg capsule
    Medfence Labs₹89.00💰 47% CHEAPER

Medical Note: Always consult your doctor before switching medications. Generic alternatives with same salts are therapeutically equivalent.

🔬 Drug Interactions

⚠️ Drug Severity Effect
Warfarin Moderate Increased INR and bleeding risk
Clopidogrel Major Reduced clopidogrel efficacy
Methotrexate Major Increased methotrexate toxicity
Ketoconazole Moderate Reduced ketoconazole absorption
Digoxin Moderate Possible increased digoxin levels
Fluconazole Major Increased pantoprazole levels
Rifampin Major Decreased pantoprazole efficacy

🚨 Major Interactions

  • CYP2C19 inhibitors (e.g., fluconazole)
  • CYP2C19 inducers (e.g., rifampin)
  • Methotrexate
  • Clopidogrel

⚡ Moderate Interactions

  • Anticoagulants (warfarin)
  • Digoxin
  • Ketoconazole
  • Iron salts

ℹ️ Minor Interactions

  • Sucralfate
  • Antacids

🍽️ Food Interactions

Food delays absorption of pantoprazole; levosulpiride absorption unaffected

🍷 Alcohol Interaction

May increase risk of GI irritation; avoid alcohol

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, GI obstruction, hemorrhage, perforation, concomitant use with clopidogrel (for pantoprazole)

📊 Monitoring Parameters

Liver function, renal function, serum electrolytes, ECG (QT interval)

🤱 Lactation Safety

Caution; levosulpiride excreted in milk, pantoprazole unknown

💊 Overdose Management

Symptomatic and supportive; no specific antidote

⏰ Missed Dose

Take as soon as remembered; skip if near next dose

🛑 Myths vs. Facts about antop-lsr capsule

  • Myth: Generic substitutes of antop-lsr capsule are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Levosulpiride (75mg) + Pantoprazole (40mg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of antop-lsr capsule can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

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