amrizol-dsr capsule allopathy (Domperidone (30mg) + Esomeprazole (40mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
amrizol-dsr capsule allopathy (Domperidone (30mg) + Esomeprazole (40mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Nuorik Healthcare. Contains Domperidone (30mg) + Esomeprazole (40mg).

Amrizol-DSR Capsule - Uses, Price, Side Effects

No reviews yet
⬆️ Click any salt to see similar medicines
🏭 Nuorik Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is amrizol-dsr capsule used for?

Amrizol-DSR Capsule is a combination medicine used to treat gastroesophageal reflux disease (GERD) and dyspepsia. It contains Domperidone, which helps control nausea and vomiting by blocking dopamine receptors, and Esomeprazole, a proton pump inhibitor that reduces stomach acid production. Together, they relieve heartburn, acid regurgitation, and stomach discomfort.

  • Generic Name: Domperidone + Esomeprazole
  • Manufacturer: Nuorik Healthcare
  • Medicine Form: Allopathy
  • Pregnancy Category: C

🇮🇳 amrizol-dsr capsule के बारे में संक्षिप्त जानकारी (Hindi Summary)

amrizol-dsr capsule का उपयोग मुख्य रूप से gastro intestinal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Domperidone (30mg) + Esomeprazole (40mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

📋 Drug Information

Generic Name(s)Domperidone + Esomeprazole
Brand NameAmrizol-DSR Capsule
ManufacturerNuorik Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at 20-25°C, protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionDomperidone: Rapidly absorbed after oral administration; Esomeprazole: Rapidly absorbed, peak plasma concentration in 1-2 hours.
DistributionDomperidone: Widely distributed, crosses blood-brain barrier minimally; Esomeprazole: High plasma protein binding, distributed in gastric parietal cells.
Protein BindingDomperidone: 91-93%; Esomeprazole: 97%.
MetabolismDomperidone: Extensive hepatic metabolism via CYP3A4; Esomeprazole: Hepatic metabolism via CYP2C19 and CYP3A4.
Half-LifeDomperidone: 7-9 hours; Esomeprazole: 1-1.5 hours.
ExcretionDomperidone: 31% urine, 66% feces; Esomeprazole: 80% urine as metabolites, 20% feces.
BioavailabilityDomperidone: 13-17%; Esomeprazole: 64-90%.
Onset of ActionDomperidone: 30-60 minutes; Esomeprazole: 1 hour.
Peak Plasma TimeDomperidone: 1 hour; Esomeprazole: 1-2 hours.
Duration of ActionDomperidone: 4-6 hours; Esomeprazole: 24 hours.

Pharmacodynamics

Mechanism of ActionDomperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Esomeprazole: Irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion.
Target ReceptorDomperidone: Dopamine D2 receptor; Esomeprazole: H+/K+ ATPase (proton pump).
Pharmacodynamic EffectsDomperidone: Increases lower esophageal sphincter pressure, accelerates gastric emptying; Esomeprazole: Raises intragastric pH, suppresses acid secretion.

📅 When to take amrizol-dsr capsule?

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

💡 How and when to take amrizol-dsr capsule?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at 20-25°C, protect from light and moisture.

⚙️ How amrizol-dsr capsule Works

Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Esomeprazole: Irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion.

1 Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and GI tract.
⬇️
2 This increases lower esophageal sphincter pressure and enhances gastric motility.
⬇️
3 Esomeprazole accumulates in the acidic canaliculi of parietal cells.
⬇️
4 It is protonated and converted to the active sulfenamide form.
⬇️
5 The active form binds covalently to H+/K+ ATPase, irreversibly inhibiting the proton pump.
⬇️
6 This results in profound and sustained reduction of gastric acid secretion.

💊 amrizol-dsr capsule Uses in Hindi (Ke Fayde), Benefits & Indications

Gastroesophageal reflux disease, dyspepsia, gastroparesis, nausea and vomiting.

Off-label uses: Migraine-associated nausea, cyclic vomiting syndrome.

⚠️ What are the side effects of amrizol-dsr capsule?

✅ Common Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Dry mouth

🚨 Serious Side Effects

  • QT prolongation
  • Torsades de pointes
  • Gynecomastia
  • Hyperprolactinemia
  • Clostridium difficile infection

⚠️ Rare Side Effects

  • Jaundice
  • Interstitial nephritis
  • Anaphylaxis
  • Extrapyramidal symptoms

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug Severity Effect
Ketoconazole Moderate Increased risk of QT prolongation
Warfarin Moderate Altered anticoagulant effect
Cilostazol Minor Increased cilostazol levels

🚨 Major Interactions

  • Ketoconazole
  • Erythromycin
  • Clarithromycin
  • Ritonavir
  • Amiodarone

⚡ Moderate Interactions

  • Cimetidine
  • Fluconazole
  • Voriconazole
  • Diltiazem
  • Verapamil

ℹ️ Minor Interactions

  • Sucralfate
  • Antacids
  • Digoxin

🍽️ Food Interactions

Food may delay absorption of domperidone; esomeprazole should be taken before meals for optimal effect.

🍷 Alcohol Interaction

Alcohol may increase gastric irritation and reduce drug efficacy.

🛡️ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category C

🚫 Contraindications

Hypersensitivity, gastrointestinal hemorrhage, mechanical obstruction, perforation, prolactinoma, concurrent use with QT-prolonging drugs.

📊 Monitoring Parameters

ECG for QT interval, renal function, hepatic function, serum electrolytes.

🤱 Lactation Safety

Domperidone is excreted in breast milk; esomeprazole is likely excreted. Use with caution.

💊 Overdose Management

Supportive care, ECG monitoring, activated charcoal if recent ingestion.

⏰ Missed Dose

Take as soon as remembered; skip if almost time for next dose. Do not double dose.

🛑 Myths vs. Facts about amrizol-dsr capsule

  • Myth: Generic substitutes of amrizol-dsr capsule are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Domperidone (30mg) + Esomeprazole (40mg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of amrizol-dsr capsule can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

💬 Real Patient Experiences (Astitva)

Join Community

Read real stories and discussions from our patient community regarding similar health conditions.

Migraine Relief: Triggers, Treatment & Home Remedies

Namaste, and welcome to the Astitva Health Community. As your doctor, I understand how debilitating a migraine or a severe headache can be. It’s not just a “headache”—it’s a neurological storm that can stop your life in its tracks. Whether it’s the throbbing pain on one side of your head, sensitivity to light, or that nauseating feeling, you deserve relief. Let’s dive deep into understanding your triggers and the medical management that can help you regain control. Understanding Your Triggers: The Root Cause Migraines are often triggered by specific factors. Identifying these is your first step toward prevention. Common triggers in the Indian context include: Dietary Triggers: Skipping meals, eating too much masala (spices), or consuming aged cheese, processed meats, or fermented foods. Even chai or coffee withdrawal can be a trigger. Hormonal Changes: Many women experience migraines around their menstrual cycle due to fluctuating estrogen levels. Environmental Factors: Bright sunlight, strong smells (like agarbatti or perfumes), pollution, or sudden weather changes. Stress & Sleep: High stress from work, family, or exams, along with irregular sleep patterns (sleeping too little or too much), are major triggers. Dehydration & Heat: Not drinking enough water, especially during Indian summers, can easily trigger a headache. Medical Management: What Actually Works? When a migraine strikes, don’t just “bear the pain.” Here’s a step-by-step medical approach: Immediate Relief (Acute Treatment) Over-the-Counter (OTC) Medications: Paracetamol (Crocin) or Ibuprofen (Brufen) can help for mild attacks. But for severe migraines, these may not be enough. Prescription Medications: Your doctor may prescribe Triptans (like Sumatriptan or Rizatriptan) which are gold-standard for migraines. They work by constricting blood vessels in the brain. Anti-nausea drugs: If vomiting is a problem, Domperidone or Metoclopramide can help. Rest in a Dark, Quiet Room: This is not a luxury—it’s essential. Close the curtains, avoid screens, and apply a cold compress to your forehead or neck. Preventive (Prophylactic) Treatment If you have 4 or more migraine attacks per month, your doctor may recommend daily preventive medications. These include: Beta-blockers like Propranolol (often used for high BP but excellent for migraines). Antidepressants like Amitriptyline (in low doses). Antiepileptics like Topiramate or Valproate. Botox injections for chronic migraines (approved by experts). Home Remedies & Diet: Your Daily Shield Alongside medical treatment, these simple Indian remedies can make a huge difference: Stay Hydrated: Drink at least 8-10 glasses of water daily. Add a pinch of sendha namak (rock salt) and lemon for electrolytes. Ginger Tea: Boil fresh ginger in water. Ginger has anti-inflammatory properties and can reduce nausea. Adrak ki chai is a powerful ally. Magnesium-Rich Foods: Eat pumpkin seeds, almonds, spinach, and bananas. Magnesium deficiency is linked to migraines. Cold Compress: Wrap ice in a cloth and place it on your forehead or temples for 15 minutes. It numbs the pain and reduces blood flow. Peppermint Oil: Apply a drop of peppermint oil diluted with coconut oil on your temples. It has a cooling, pain-relieving effect. Avoid Processed Foods: Cut down on maida (refined flour), packaged chips, and sugary drinks. These can trigger inflammation. When to See a Doctor Immediately While most headaches are benign, you must seek urgent medical help if you experience: A sudden, explosive headache (like a “thunderclap”). Headache with fever, stiff neck, or rash. Headache after a head injury. Weakness on one side of the body, slurred speech, or vision loss. New headaches after age 50. Remember, you are not alone. Migraine is a medical condition, not a character flaw. With the right triggers management and medical plan, you can live a full, pain-free life. Stay strong, stay informed, and always consult your doctor before starting any new treatment. Take care of your astitva—your existence—because your health is your greatest wealth.

Browse SaathiMed's Medicines A-Z

Search our extensive medical database alphabetically to find uses, price, composition, and side effects.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory
SaathiMed App
SaathiMed App Consult doctors & order medicines faster
Install