amlopump-at tablet - Uses, Price, Side Effects & Substitutes
What is amlopump-at tablet used for?
Amlokind-AT Tablet (Amlodipine + Atenolol) is used to treat CARDIAC. It contains Amlodipine (5mg) + Atenolol (50mg), which Amlodipine inhibits calcium influx across cell membranes in vascular smooth musc. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amlodipine + Atenolol
- Manufacturer: Avighna Medicare Pvt. Ltd.
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ amlopump-at tablet Uses & Benefits
Hypertension, angina pectoris (chronic stable angina, vasospastic angina)
๐ Drug Information
| Generic Name(s) | Amlodipine + Atenolol |
| Brand Name | Amlokind-AT Tablet |
| Manufacturer | Avighna Medicare Pvt. Ltd. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Calcium channel blocker + Beta blocker |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amlodipine inhibits calcium influx across cell membranes in vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced peripheral resistance. Atenolol selectively blocks beta-1 adrenergic receptors, decreasing heart rate, contractility, and cardiac output.
Mechanism Steps
๐ก How to Take amlopump-at tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amlopump-at tablet
โ Common Side Effects
- Edema (ankle/foot)
- Headache
- Dizziness
- Fatigue
- Nausea
- Flushing
- Palpitations
- Bradycardia
- Cold extremities
๐จ Serious Side Effects
- Severe hypotension
- Heart failure exacerbation
- Bradyarrhythmias
- Bronchospasm
- Hepatotoxicity (rare)
- Stevens-Johnson syndrome (rare)
โ ๏ธ Rare Side Effects
- Gingival hyperplasia
- Leukopenia
- Thrombocytopenia
- Vasculitis
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | Increased risk of bradycardia, heart block, and hypotension |
| Clonidine | Major | Rebound hypertension upon clonidine withdrawal |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Grapefruit juice | Minor | Increased amlodipine levels |
๐จ Major Interactions
- Beta blockers (other)
- Calcium channel blockers (verapamil, diltiazem)
- CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir)
- Clonidine
- Digitalis glycosides
โก Moderate Interactions
- NSAIDs
- Antihypertensives (additive effect)
- Insulin
- Oral hypoglycemics
- Anesthetics
โน๏ธ Minor Interactions
- Cimetidine
- Grapefruit juice (amlodipine)
- Antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid excessive intake. Food does not significantly affect atenolol absorption.
๐ท Alcohol Interaction
Alcohol may enhance hypotensive effect; avoid excessive alcohol consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to components, cardiogenic shock, severe bradycardia, heart block (2nd/3rd degree), sick sinus syndrome, severe hypotension, acute heart failure, asthma/COPD (atenolol), peripheral vascular disease (severe)
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, serum electrolytes, renal function, hepatic function, blood glucose (in diabetics)
๐คฑ Lactation Safety
Low risk; both drugs excreted in breast milk in small amounts. Caution advised.
๐ Overdose Management
Supportive care; atropine for bradycardia, vasopressors for hypotension, calcium gluconate for calcium channel blocker overdose, glucagon for beta blocker overdose
โฐ Missed Dose
Take as soon as remembered if within 12 hours; skip if close to next dose. Do not double dose.