amira p 0.25mg/20mg tablet - Uses, Price, Side Effects & Substitutes
What is amira p 0.25mg/20mg tablet used for?
Ambulax Tablet (Alprazolam + Propranolol) is used to treat NEURO CNS. It contains Alprazolam (0.25mg) + Propranolol (20mg), which Alprazolam enhances GABA-A receptor activity; Propranolol blocks beta-adrenergic. Always consult your doctor before use. Take as prescribed.
- Generic Name: Alprazolam + Propranolol
- Manufacturer: Durpha Lifesciences
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amira p 0.25mg/20mg tablet Uses & Benefits
Anxiety disorders, panic disorder, performance anxiety, essential tremor, situational anxiety
Off-label uses: Insomnia, premenstrual dysphoric disorder, social phobia, migraine prophylaxis
๐ Drug Information
| Generic Name(s) | Alprazolam + Propranolol |
| Brand Name | Ambulax Tablet |
| Manufacturer | Durpha Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepine + Beta-blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Alprazolam enhances GABA-A receptor activity; Propranolol blocks beta-adrenergic receptors
Mechanism Steps
๐ก How to Take amira p 0.25mg/20mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amira p 0.25mg/20mg tablet
โ Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Dry mouth
- Nausea
- Constipation
- Bradycardia
- Hypotension
๐จ Serious Side Effects
- Respiratory depression
- Severe bradycardia
- Heart block
- Hypotension
- Seizures
- Suicidal thoughts
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Jaundice
- Agranulocytosis
- Thrombocytopenia
- Stevens-Johnson syndrome
- Bronchospasm
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased alprazolam levels and toxicity |
| Quinidine | Major | Increased propranolol levels and bradycardia |
| Alcohol | Major | Enhanced CNS depression and sedation |
| Warfarin | Moderate | Possible increased INR |
| Digoxin | Moderate | Increased risk of bradycardia |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., quinidine)
- Other CNS depressants
- Calcium channel blockers
- Antiarrhythmics
โก Moderate Interactions
- Oral hypoglycemics
- Theophylline
- Warfarin
- Digoxin
- MAO inhibitors
โน๏ธ Minor Interactions
- Cimetidine
- Oral contraceptives
- Antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice (increases alprazolam levels), High-fat meals may delay absorption
๐ท Alcohol Interaction
Avoid; increased CNS depression and sedation
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, acute narrow-angle glaucoma, severe COPD, asthma, bradycardia, heart block, uncompensated heart failure, myasthenia gravis, severe hepatic impairment
๐ Monitoring Parameters
Heart rate, blood pressure, respiratory rate, sedation level, liver function tests, renal function
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk
๐ Overdose Management
Supportive care; flumazenil for alprazolam overdose; atropine, beta-agonists for propranolol overdose
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose