amifru-s tablet - Uses, Price, Side Effects & Substitutes
What is amifru-s tablet used for?
Aldostix 20 mg/50 mg tablet (Furosemide + Spironolactone) is used to treat Edema (CHF. It contains Furosemide (20mg) + Spironolactone (50mg), which Furosemide inhibits Na-K-2Cl cotransporter in thick ascending limb of loop of He. Always consult your doctor before use. Take as prescribed.
- Generic Name: Furosemide + Spironolactone
- Manufacturer: Torrent Pharmaceuticals Ltd
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 amifru-s tablet के बारे में संक्षिप्त जानकारी (Hindi Summary)
amifru-s tablet का उपयोग मुख्य रूप से cardiac और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Furosemide (20mg) + Spironolactone (50mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Drug Information
| Generic Name(s) | Furosemide + Spironolactone |
|---|---|
| Brand Name | Aldostix 20 mg/50 mg tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Diuretic, Potassium-sparing diuretic combination |
| Route of Administration | Oral |
| Storage | Store at 20-25°C, protect from light and moisture |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
💡 How and when to take amifru-s tablet?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at 20-25°C, protect from light and moisture
⚙️ How amifru-s tablet Works
Furosemide inhibits Na-K-2Cl cotransporter in thick ascending limb of loop of Henle; Spironolactone competitively inhibits aldosterone in distal convoluted tubule, promoting Na and water excretion while retaining K
💊 amifru-s tablet Uses in Hindi (Ke Fayde), Benefits & Indications
Edema (CHF, hepatic cirrhosis, nephrotic syndrome), hypertension, primary hyperaldosteronism
Off-label uses: Polycystic ovary syndrome (spironolactone), heart failure (furosemide)
⚠️ What are the side effects of amifru-s tablet?
✅ Common Side Effects
- Hyperkalemia
- Hypokalemia (furosemide)
- Dehydration
- Dizziness
- Headache
- GI upset
- Gynecomastia (spironolactone)
🚨 Serious Side Effects
- Severe hyperkalemia
- Arrhythmias
- Acute renal failure
- Hepatic encephalopathy
- Stevens-Johnson syndrome
⚠️ Rare Side Effects
- Pancreatitis
- Agranulocytosis
- Thrombocytopenia
- Anaphylaxis
- Hepatotoxicity
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| ACE inhibitors | Major | Increased risk of hyperkalemia |
| Lithium | Major | Increased lithium toxicity |
| NSAIDs | Major | Reduced diuretic efficacy, increased nephrotoxicity |
| Digoxin | Major | Increased digoxin toxicity due to hypokalemia |
| Potassium supplements | Major | Severe hyperkalemia |
| Corticosteroids | Moderate | Increased hypokalemia risk |
| Antidiabetic agents | Moderate | Reduced hypoglycemic effect |
🚨 Major Interactions
- ACE inhibitors
- Angiotensin II receptor blockers
- Potassium supplements
- Potassium-sparing diuretics
- Lithium
- NSAIDs
- Digoxin
⚡ Moderate Interactions
- Corticosteroids
- Amphotericin B
- Antidiabetic agents
- Antihypertensives
- Cholestyramine
- Colestipol
ℹ️ Minor Interactions
- Barbiturates
- Opioids
- Alcohol
🍽️ Food Interactions
High potassium foods, Licorice
🍷 Alcohol Interaction
May increase orthostatic hypotension risk
🛡️ Safety & Warnings
🚫 Contraindications
Anuria, severe renal failure, hyperkalemia, Addison's disease, hypersensitivity to sulfonamides (furosemide), pregnancy (spironolactone)
📊 Monitoring Parameters
Serum electrolytes (K, Na, Mg, Ca), renal function, blood pressure, urine output, signs of dehydration
🤱 Lactation Safety
Furosemide excreted in milk; Spironolactone metabolite present; avoid or use with caution
💊 Overdose Management
Supportive care, monitor electrolytes, correct dehydration, treat hyperkalemia (IV calcium, insulin+glucose, kayexalate)
⏰ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close; do not double
🛑 Myths vs. Facts about amifru-s tablet
- Myth: Generic substitutes of amifru-s tablet are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Furosemide (20mg) + Spironolactone (50mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of amifru-s tablet can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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