alpalide 100mg tablet - Nimesulide (100mg) medicine

alpalide 100mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Alpa Laboratories Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is alpalide 100mg tablet used for?

Aulin 100mg Tablet (Nimesulide) is used to treat PAIN ANALGESICS. It contains Nimesulide (100mg), which Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthes. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Nimesulide
  • Manufacturer: Alpa Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š alpalide 100mg tablet Uses & Benefits

Acute pain, dysmenorrhea, postoperative pain, musculoskeletal disorders, fever.

Off-label uses: Not commonly used off-label due to safety concerns.

๐Ÿ“‹ Drug Information

Generic Name(s)Nimesulide
Brand NameAulin 100mg Tablet
ManufacturerAlpa Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's-Non-Selective COX 1&2 Inhibitors (Others)
Route of AdministrationOral
StorageStore at room temperature (15-30ยฐC), protect from moisture and light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration, with peak plasma concentrations achieved within 1-3 hours.
DistributionExtensively distributed to tissues; crosses the placenta and enters breast milk.
Protein Binding>97.5% bound to plasma proteins, primarily albumin.
MetabolismExtensively metabolized in the liver via CYP2C9 and other pathways; major metabolite is 4-hydroxynimesulide.
Half-LifeApproximately 1.8-4.7 hours.
ExcretionPrimarily renal (about 50-60% as metabolites, <1% unchanged); also biliary excretion.
BioavailabilityApproximately 100% after oral administration.
Onset of ActionWithin 15-30 minutes.
Peak Plasma Time1-3 hours.
Duration of Action6-8 hours.

How It Works

Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis.

Mechanism Steps

1Inhibition of COX-2 enzyme
2Reduction of prostaglandin synthesis from arachidonic acid
3Decreased inflammation, pain, and fever

๐Ÿ’ก How to Take alpalide 100mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of alpalide 100mg tablet

โœ… Common Side Effects

  • Nausea
  • Dyspepsia
  • Diarrhea
  • Headache
  • Dizziness
  • Rash

๐Ÿšจ Serious Side Effects

  • Hepatotoxicity
  • Gastrointestinal bleeding
  • Stevens-Johnson syndrome
  • Acute renal failure
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Thrombocytopenia
  • Agranulocytosis
  • Pancreatitis
  • Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Aspirin Major Increased risk of GI ulceration and bleeding
Methotrexate Major Increased methotrexate toxicity
Lithium Major Increased lithium levels and toxicity
Anticoagulants Major Enhanced anticoagulant effect
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic effect and increased nephrotoxicity risk
Corticosteroids Moderate Increased risk of GI ulceration
Antiplatelet agents Moderate Increased bleeding risk
Antacids Minor Slight delay in absorption
Cimetidine Minor Possible increased nimesulide levels

๐Ÿšจ Major Interactions

  • Warfarin
  • Aspirin
  • Methotrexate
  • Lithium
  • Anticoagulants

โšก Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Corticosteroids
  • Antiplatelet agents

โ„น๏ธ Minor Interactions

  • Antacids
  • Cimetidine

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption but does not significantly affect bioavailability.

๐Ÿท Alcohol Interaction

Increased risk of gastrointestinal bleeding and hepatotoxicity.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to nimesulide or NSAIDs, active peptic ulcer, severe hepatic impairment, severe renal impairment, pregnancy (third trimester), lactation, children <12 years.

๐Ÿ“Š Monitoring Parameters

Liver function tests, renal function, blood pressure, signs of GI bleeding.

๐Ÿคฑ Lactation Safety

Contraindicated; excreted in breast milk.

๐Ÿ’Š Overdose Management

Symptomatic and supportive; no specific antidote; consider activated charcoal if recent ingestion.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for alpalide 100mg tablet

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Alternative brands with exact same active ingredient (Nimesulide (100mg)):

Medical Note: Always consult your doctor before switching medications.

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