alcoderm cream - Uses, Price, Side Effects & Substitutes
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Medically Reviewed
By SaathiMed Expert Medical Panel
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💊 What is alcoderm cream used for?
Azonate G Cream (Betamethasone + Gentamicin) is used to treat Inflammatory dermatoses with secondary bacterial infection. It contains Betamethasone (0.5mg) + Gentamicin (1mg), which Betamethasone: Suppresses inflammation by inhibiting phospholipase A2, reducing . Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Betamethasone + Gentamicin
Betamethasone + Gentamicin
🏭 Manufacturer
Alicon Pharmaceutical Pvt Ltd
Alicon Pharmaceutical Pvt Ltd
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category A
Category A
🇮🇳 alcoderm cream के बारे में संक्षिप्त जानकारी
alcoderm cream का उपयोग मुख्य रूप से derma और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Betamethasone (0.5mg) + Gentamicin (1mg) मौजूद है।
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.
📋 Complete Drug Information
| Generic Name(s) | Betamethasone + Gentamicin |
|---|---|
| Brand Name | Azonate G Cream |
| Manufacturer | Alicon Pharmaceutical Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Corticosteroid + Aminoglycoside Antibiotic |
| Route of Administration | Topical |
| Storage | Store at 20-25°C (68-77°F); protect from light and moisture. |
🔬 Pharmacology
Pharmacokinetics
AbsorptionTopical absorption varies; enhanced by inflamed skin or occlusion.
DistributionDistributes locally; minimal systemic absorption with intact skin.
Protein BindingBetamethasone: ~64%; Gentamicin: <30%.
MetabolismBetamethasone: Hepatic via CYP3A4; Gentamicin: Not metabolized.
Half-LifeBetamethasone: 36-54 hours; Gentamicin: 2-3 hours (topical).
ExcretionBetamethasone: Renal; Gentamicin: Renal (unchanged).
BioavailabilityLow systemic bioavailability with topical use.
Onset of ActionWithin days for anti-inflammatory effect.
Peak Plasma TimeNot applicable for topical use.
Duration of ActionVaries; typically 12-24 hours with once or twice daily application.
Mechanism of Action
Betamethasone: Suppresses inflammation by inhibiting phospholipase A2, reducing prostaglandin and leukotriene synthesis. Gentamicin: Binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis.
Step-by-Step Mechanism
1
Betamethasone binds to glucocorticoid receptor in cytoplasm.
2
Complex translocates to nucleus, modulates gene transcription.
3
Inhibits phospholipase A2, reducing arachidonic acid release.
4
Decreases prostaglandin and leukotriene synthesis.
5
Suppresses inflammatory cytokine production.
6
Gentamicin diffuses across bacterial cell membrane.
7
Binds to 30S ribosomal subunit, misreads mRNA.
8
Inhibits protein synthesis, leading to bacterial cell death.
💡 How to take alcoderm cream
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at 20-25°C (68-77°F); protect from light and moisture.
⚠️ Side Effects of alcoderm cream
✅ Common Side Effects
- Burning
- itching
- irritation
- dryness
- folliculitis
🚨 Serious Side Effects
- Adrenal suppression
- Cushing's syndrome
- Hypersensitivity reactions
- Ototoxicity
- Nephrotoxicity
⚠️ Rare Side Effects
- Perioral dermatitis
- Allergic contact dermatitis
- Secondary infection
- Skin atrophy
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Possible increased anticoagulant effect |
| Loop diuretics | Major | Increased risk of ototoxicity and nephrotoxicity |
| Neuromuscular blockers | Major | Enhanced neuromuscular blockade |
🚨 Major Interactions
- Aminoglycosides (systemic)
- Neuromuscular blocking agents
- Loop diuretics
⚡ Moderate Interactions
- Anticoagulants
- NSAIDs
- Antidiabetic agents
🍷 Alcohol Interaction
No significant interaction.
🛡️ Safety & Warnings
Pregnancy
Category A
Liver Risk
Low
Kidney Risk
Low
Heart Risk
Low
🚫 Contraindications
Hypersensitivity to betamethasone, gentamicin, or any component; untreated bacterial, fungal, or viral infections; perioral dermatitis; rosacea.
📊 Monitoring Parameters
Assess skin for improvement or signs of infection; monitor for systemic effects with prolonged use.
🤱 Lactation Safety
Use with caution; avoid application to breast area.
💊 Overdose
Discontinue use; symptomatic treatment for systemic effects if extensive absorption.
⏰ Missed Dose
Apply as soon as remembered; skip if almost time for next dose.