afogatran 110 capsule - Uses, Price, Side Effects & Substitutes
What is afogatran 110 capsule used for?
Afogatran 110 Capsule (Dabigatran Etexilate) is used to treat Stroke prevention in non-valvular atrial fibrillation; treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE); prevention of recurrent DVT/PE; thromboprophylaxis after hip or knee replacement surgery.. It contains Dabigatran Etexilate (110mg), which Direct, reversible inhibition of free and clot-bound thrombin (factor IIa), prev. Always consult your doctor before use. Take as prescribed.
- Generic Name: Dabigatran Etexilate
- Manufacturer: Torrent Pharmaceuticals Ltd
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 afogatran 110 capsule के बारे में संक्षिप्त जानकारी (Hindi Summary)
afogatran 110 capsule का उपयोग मुख्य रूप से cardiac और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Dabigatran Etexilate (110mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.
📋 Drug Information
| Generic Name(s) | Dabigatran Etexilate |
|---|---|
| Brand Name | Afogatran 110 Capsule |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Direct thrombin inhibitor- oral |
| Route of Administration | Oral. |
| Storage | Store at room temperature (20-25°C); protect from moisture; keep in original container. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
💡 How and when to take afogatran 110 capsule?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at room temperature (20-25°C); protect from moisture; keep in original container.
⚙️ How afogatran 110 capsule Works
Direct, reversible inhibition of free and clot-bound thrombin (factor IIa), preventing fibrin formation.
💊 afogatran 110 capsule Uses in Hindi (Ke Fayde), Benefits & Indications
Stroke prevention in non-valvular atrial fibrillation; treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE); prevention of recurrent DVT/PE; thromboprophylaxis after hip or knee replacement surgery.
Off-label uses: Anticoagulation in patients with heparin-induced thrombocytopenia (HIT); off-label use in pediatric patients (limited data).
⚠️ What are the side effects of afogatran 110 capsule?
✅ Common Side Effects
- Dyspepsia
- Gastritis
- Abdominal pain
- Diarrhea
- Nausea
- Bleeding (minor: epistaxis, hematuria, bruising)
🚨 Serious Side Effects
- Major bleeding (intracranial, gastrointestinal, retroperitoneal)
- Hemorrhagic stroke
- Spinal hematoma with neuraxial anesthesia
- Acute renal failure
⚠️ Rare Side Effects
- Allergic reactions (urticaria, anaphylaxis)
- Hepatotoxicity (elevated liver enzymes)
- Thrombocytopenia
- Esophagitis
- Alopecia
Consult your doctor if you experience any unusual symptoms.
🔄 Best Substitutes for afogatran 110 capsule
View AllAlternative brands with exact same active ingredient and strength (Dabigatran Etexilate (110mg)):
- dabigo 110mg capsuleSun Pharmaceutical Industries Ltd₹154.51💰 54.5% CHEAPER
- dabimend 110 capsuleMendcure Life Sciences Pvt Ltd₹210.94💰 37.9% CHEAPER
- dabxiga 110mg capsuleLupin Ltd₹225.00💰 33.8% CHEAPER
- dabitra 110 capsuleEmcure Pharmaceuticals Ltd₹225.00💰 33.8% CHEAPER
- dabanex 110mg capsuleAjanta Pharma Ltd₹250.00💰 26.4% CHEAPER
- dabiac 110mg capsuleChemo Healthcare Pvt Ltd₹261.56💰 23% CHEAPER
- Dabicoast CapsuleWest-Coast Pharmaceutical Works Ltd₹265.00💰 22% CHEAPER
- macdaxa 110mg capsuleMacleods Pharmaceuticals Pvt Ltd₹270.00💰 20.5% CHEAPER
- bigatra 110mg tabletAprica Pharmaceuticals Pvt Ltd₹271.88💰 20% CHEAPER
- dabiten 110mg capsuleAlteus Biogenics Pvt Ltd₹281.25💰 17.2% CHEAPER
Medical Note: Always consult your doctor before switching medications. Generic alternatives with same salts are therapeutically equivalent.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Heparin | Major | Increased bleeding risk |
| Clopidogrel | Major | Increased bleeding risk |
| Aspirin | Major | Increased bleeding risk |
| Verapamil | Major | Increased dabigatran exposure (P-gp inhibition) |
| Amiodarone | Major | Increased dabigatran exposure (P-gp inhibition) |
| Rifampin | Major | Decreased dabigatran exposure (P-gp induction) |
| St. John's wort | Major | Decreased dabigatran exposure (P-gp induction) |
| Ibuprofen | Moderate | Increased bleeding risk |
| Omeprazole | Minor | Slight decrease in dabigatran absorption |
🚨 Major Interactions
- Anticoagulants (warfarin, heparin)
- Antiplatelet agents (clopidogrel, aspirin)
- Thrombolytics
- P-glycoprotein inhibitors (verapamil, amiodarone, quinidine)
- P-glycoprotein inducers (rifampin, St. John's wort)
⚡ Moderate Interactions
- NSAIDs (ibuprofen, naproxen)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
- Other anticoagulants (fondaparinux, rivaroxaban)
ℹ️ Minor Interactions
- Antacids (aluminum/magnesium hydroxide)
- Proton pump inhibitors (omeprazole)
- H2 receptor antagonists (ranitidine)
🍽️ Food Interactions
Food delays absorption but does not significantly affect overall bioavailability; avoid grapefruit juice (may increase absorption via P-gp inhibition).
🍷 Alcohol Interaction
Alcohol may increase bleeding risk due to additive anticoagulant effect; avoid excessive consumption.
🛡️ Safety & Warnings
🚫 Contraindications
Active pathological bleeding; severe renal impairment (CrCl <15 mL/min); mechanical prosthetic heart valve; hypersensitivity to dabigatran; hepatic impairment with coagulopathy.
📊 Monitoring Parameters
Renal function (CrCl) at baseline and periodically; signs of bleeding; aPTT, TT, or ECT may be used to assess anticoagulant effect if needed.
🤱 Lactation Safety
Not recommended; excreted in breast milk in animal studies; potential for bleeding in infant.
💊 Overdose Management
Activated charcoal if recent ingestion; hemodialysis may remove dabigatran; idarucizumab (specific reversal agent) for life-threatening bleeding; supportive care.
⏰ Missed Dose
If missed dose, take as soon as remembered if within 6 hours of scheduled time; otherwise skip and take next dose at regular time; do not double dose.
🛑 Myths vs. Facts about afogatran 110 capsule
- Myth: Generic substitutes of afogatran 110 capsule are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Dabigatran Etexilate (110mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of afogatran 110 capsule can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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