aeknil injection - Uses, Price, Side Effects & Substitutes
Paracetamol (150mg)
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Medically Reviewed
By SaathiMed Expert Medical Panel
⭐ ZERO POSITION
💊 What is aeknil injection used for?
Action or 1000mg Tablet (Paracetamol) is used to treat Mild to moderate pain (headache. It contains Paracetamol (150mg), which Inhibits cyclooxygenase (COX) in the central nervous system, reducing prostaglan. Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Paracetamol
Paracetamol
🏭 Manufacturer
Therapeutic Pharmaceuticals
Therapeutic Pharmaceuticals
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category A
Category A
🇮🇳 aeknil injection के बारे में संक्षिप्त जानकारी
aeknil injection का उपयोग मुख्य रूप से pain analgesics और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Paracetamol (150mg) मौजूद है।
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.
📋 Complete Drug Information
| Generic Name(s) | Paracetamol |
|---|---|
| Brand Name | Action or 1000mg Tablet |
| Manufacturer | Therapeutic Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Analgesic & Antipyretic-PCM |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C); protect from light and moisture. |
🔬 Pharmacology
Pharmacokinetics
AbsorptionRapidly and completely absorbed from the gastrointestinal tract.
DistributionWidely distributed throughout body fluids; crosses placenta and appears in breast milk.
Protein Binding10-25%
MetabolismHepatic via conjugation (glucuronidation and sulfation); minor oxidation via CYP2E1.
Half-Life1.5-3 hours
ExcretionRenal (90-100% as metabolites within 24 hours).
Bioavailability75-85%
Onset of Action30-60 minutes
Peak Plasma Time30-60 minutes
Duration of Action4-6 hours
Mechanism of Action
Inhibits cyclooxygenase (COX) in the central nervous system, reducing prostaglandin synthesis; also activates descending serotonergic pathways.
Step-by-Step Mechanism
1
Inhibition of COX-1 and COX-2 in the central nervous system
2
Reduction of prostaglandin synthesis in the hypothalamus
3
Activation of descending serotonergic pathways
4
Modulation of cannabinoid receptors (indirect)
5
Antagonism of TRPV1 receptors
💡 How to take aeknil injection
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at room temperature (15-30°C); protect from light and moisture.
⚠️ Side Effects of aeknil injection
✅ Common Side Effects
- Nausea
- Vomiting
- Constipation
- Rash
🚨 Serious Side Effects
- Hepatotoxicity
- Acute liver failure
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Acute generalized exanthematous pustulosis
⚠️ Rare Side Effects
- Thrombocytopenia
- Leukopenia
- Neutropenia
- Pancreatitis
- Hypersensitivity reactions
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk with high doses of paracetamol |
| Alcohol | Major | Increased hepatotoxicity risk |
| Isoniazid | Major | Increased hepatotoxicity risk |
| Rifampin | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Carbamazepine | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Phenytoin | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Barbiturates | Major | Reduced paracetamol efficacy; increased hepatotoxicity |
| Cholestyramine | Moderate | Reduced absorption of paracetamol |
| Metoclopramide | Moderate | Increased absorption rate of paracetamol |
| Domperidone | Moderate | Increased absorption rate of paracetamol |
| Probenecid | Moderate | Reduced clearance of paracetamol |
| Oral contraceptives | Moderate | Reduced analgesic effect of paracetamol |
| Caffeine | Minor | Enhanced analgesic effect |
| Zidovudine | Minor | Increased risk of neutropenia |
| Lamotrigine | Minor | Reduced lamotrigine efficacy |
🚨 Major Interactions
- Warfarin
- Alcohol (chronic heavy use)
- Isoniazid
- Rifampin
- Carbamazepine
- Phenytoin
- Barbiturates
⚡ Moderate Interactions
- Cholestyramine
- Metoclopramide
- Domperidone
- Probenecid
- Oral contraceptives
🍽️ Food Interactions
Food may delay absorption; high-fat meals reduce peak concentration.
🍷 Alcohol Interaction
Chronic heavy alcohol use increases hepatotoxicity risk; avoid concurrent use.
🛡️ Safety & Warnings
Pregnancy
Category A
Liver Risk
Low
Kidney Risk
Low
Heart Risk
Low
🚫 Contraindications
Hypersensitivity to paracetamol; severe hepatic impairment; chronic alcoholism.
📊 Monitoring Parameters
Liver function tests (in overdose or chronic high doses); renal function in long-term use.
🤱 Lactation Safety
Excreted in breast milk in small amounts; considered safe at therapeutic doses.
💊 Overdose
Activated charcoal if within 1 hour; N-acetylcysteine (NAC) as antidote; monitor liver function.
⏰ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose; do not double dose.