adacin gel - Adapalene (0.1% w/w) + Clindamycin (1% w/w) medicine

adacin gel - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Ajanta Pharma Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is adacin gel used for?

Acnesol A Nano Gel (Adapalene + Clindamycin) is used to treat DERMA. It contains Adapalene (0.1% w/w) + Clindamycin (1% w/w), which Adapalene binds to retinoic acid receptors (RARs) to normalize follicular kerati. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Adapalene + Clindamycin
  • Manufacturer: Ajanta Pharma Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š adacin gel Uses & Benefits

Acne vulgaris (inflammatory and non-inflammatory lesions)

Off-label uses: Keratosis pilaris, Photodamage, Melasma

๐Ÿ“‹ Drug Information

Generic Name(s)Adapalene + Clindamycin
Brand NameAcnesol A Nano Gel
ManufacturerAjanta Pharma Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassRetinoid + Antibiotic
Route of AdministrationTopical
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and heat
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption; primarily local cutaneous absorption
DistributionNot extensively studied; limited systemic distribution
Protein BindingAdapalene: >95% bound to plasma proteins; Clindamycin: ~60-94% bound
MetabolismAdapalene: Hepatic via CYP2C9 and CYP3A4; Clindamycin: Hepatic via CYP3A4
Half-LifeAdapalene: ~7-12 hours; Clindamycin: ~2-3 hours
ExcretionAdapalene: Biliary; Clindamycin: Renal and biliary
BioavailabilityLow systemic bioavailability due to topical application
Onset of Action2-4 weeks
Peak Plasma TimeNot applicable for topical use
Duration of ActionNot specified; applied once daily

How It Works

Adapalene binds to retinoic acid receptors (RARs) to normalize follicular keratinization; Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit

Mechanism Steps

1Adapalene binds to RAR-ฮฒ and RAR-ฮณ receptors in keratinocytes
2Modulates gene expression to normalize follicular keratinization
3Reduces microcomedone formation and comedogenesis

๐Ÿ’ก How to Take adacin gel

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of adacin gel

โœ… Common Side Effects

  • Skin dryness
  • Erythema
  • Peeling
  • Burning
  • Stinging
  • Pruritus

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • Severe allergic reactions
  • Photosensitivity

โš ๏ธ Rare Side Effects

  • Contact dermatitis
  • Hyperpigmentation
  • Hypopigmentation

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Erythromycin Major Antagonism of clindamycin antibacterial effect
Tetracyclines Major Increased risk of pseudomembranous colitis
Systemic retinoids Major Increased risk of hypervitaminosis A
Neuromuscular blocking agents Major Enhanced neuromuscular blockade
Topical corticosteroids Moderate May reduce efficacy of adapalene
Topical benzoyl peroxide Moderate May cause skin irritation; use with caution
Other topical antibiotics Moderate Possible cross-resistance or irritation

๐Ÿšจ Major Interactions

  • Erythromycin
  • Tetracyclines
  • Systemic retinoids
  • Neuromuscular blocking agents

โšก Moderate Interactions

  • Topical corticosteroids
  • Topical benzoyl peroxide
  • Other topical antibiotics

โ„น๏ธ Minor Interactions

  • Cosmetics with drying or abrasive effects

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to adapalene, clindamycin, or any component; history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis

๐Ÿ“Š Monitoring Parameters

Skin irritation, dryness, peeling; signs of infection; pregnancy status

๐Ÿคฑ Lactation Safety

Caution; not recommended during breastfeeding

๐Ÿ’Š Overdose Management

Excessive topical application may cause severe irritation; treat symptomatically; accidental ingestion may cause gastrointestinal effects; supportive care

โฐ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

๐Ÿ”— View Profile

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