acitrin 25mg capsule allopathy (Acitretin (25mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
acitrin 25mg capsule allopathy (Acitretin (25mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Ipca Laboratories Ltd. Contains Acitretin (25mg).

acitrin 25mg capsule - Uses, Price, Side Effects & Substitutes

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Acitretin (25mg) (Click to see all medicines with same salt)
🏭 Ipca Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is acitrin 25mg capsule used for?

Acrotac 25mg Capsule (Acitretin) is used to treat Severe psoriasis (plaque. It contains Acitretin (25mg), which Binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulat. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Acitretin
  • Manufacturer: Ipca Laboratories Ltd
  • Medicine Form: Allopathy
  • Pregnancy Category: A

🇮🇳 acitrin 25mg capsule के बारे में संक्षिप्त जानकारी (Hindi Summary)

acitrin 25mg capsule का उपयोग मुख्य रूप से derma और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Acitretin (25mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Acitrin 25mg Capsule is a medicine that is similar to vitamin A and is involved in the normal growth of skin cells. It is used in the treatment of pso... Read more below.

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

📋 Drug Information

Generic Name(s)Acitretin
Brand NameAcrotac 25mg Capsule
ManufacturerIpca Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassRetinoids- Second generation
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F); protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; bioavailability increased with food.
DistributionExtensively distributed; highly protein-bound (>99%) to albumin.
Protein Binding>99%
MetabolismHepatic; isomerizes to cis-acitretin and undergoes glucuronidation; also metabolized to etretinate (minor).
Half-Life50 hours (acitretin); 120 hours (cis-acitretin); etretinate up to 120 days.
ExcretionRenal and fecal; as metabolites.
Bioavailability60-70% (increased with food)
Onset of Action2-4 weeks
Peak Plasma Time2-4 hours
Duration of ActionSeveral weeks after discontinuation due to slow elimination.

Pharmacodynamics

Mechanism of ActionBinds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulating gene transcription involved in cell differentiation, proliferation, and keratinization.
Target ReceptorRetinoic acid receptors (RAR-α, β, γ) and retinoid X receptors (RXR-α, β, γ)
Pharmacodynamic EffectsReduces keratinocyte hyperproliferation, normalizes differentiation, and has anti-inflammatory effects.

💡 How and when to take acitrin 25mg capsule?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at 20-25°C (68-77°F); protect from light and moisture.

⚙️ How acitrin 25mg capsule Works

Binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulating gene transcription involved in cell differentiation, proliferation, and keratinization.

1 Binds to cellular retinoic acid-binding proteins (CRABPs) and translocates to nucleus.
⬇️
2 Interacts with retinoic acid receptors (RARs) and retinoid X receptors (RXRs).
⬇️
3 Forms heterodimers with RXR and binds to retinoic acid response elements (RAREs) on DNA.
⬇️
4 Modulates transcription of genes regulating cell growth, differentiation, and apoptosis.
⬇️
5 Reduces keratinocyte proliferation and normalizes epidermal differentiation.

💊 acitrin 25mg capsule Uses in Hindi (Ke Fayde), Benefits & Indications

Severe psoriasis (plaque, pustular, erythrodermic), disorders of keratinization (e.g., ichthyosis, Darier disease).

Off-label uses: Prevention of skin cancers (non-melanoma), lichen planus, lupus erythematosus.

⚠️ What are the side effects of acitrin 25mg capsule?

✅ Common Side Effects

  • Cheilitis
  • Dry skin
  • Alopecia
  • Hyperlipidemia
  • Elevated LFTs
  • Rhinorrhea
  • Xerophthalmia

🚨 Serious Side Effects

  • Hepatotoxicity
  • Pseudotumor cerebri
  • Pancreatitis
  • Severe depression/suicidal ideation
  • Teratogenicity

⚠️ Rare Side Effects

  • Osteoporosis
  • Premature epiphyseal closure
  • Thrombocytopenia
  • Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug Severity Effect
Methotrexate Major Increased risk of hepatotoxicity
Tetracyclines Major Increased risk of pseudotumor cerebri
Vitamin A supplements Major Additive toxicity (hypervitaminosis A)
Oral contraceptives Major Reduced contraceptive efficacy
Phenytoin Moderate Altered phenytoin levels
Warfarin Moderate Increased anticoagulant effect
Corticosteroids Moderate Increased risk of osteoporosis
Alcohol Minor Increased hepatotoxicity risk
Grapefruit juice Minor May alter metabolism

🚨 Major Interactions

  • Methotrexate
  • Tetracyclines
  • Vitamin A supplements
  • Oral contraceptives (reduced efficacy)

⚡ Moderate Interactions

  • Phenytoin
  • Warfarin
  • Corticosteroids

ℹ️ Minor Interactions

  • Alcohol
  • Grapefruit juice

🍽️ Food Interactions

High-fat meals increase absorption.

🍷 Alcohol Interaction

May increase hepatotoxicity risk; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Pregnancy, breastfeeding, severe hepatic/renal impairment, hypersensitivity to retinoids, concomitant use with methotrexate or tetracyclines.

📊 Monitoring Parameters

LFTs, serum lipids, renal function, pregnancy test (monthly), blood glucose, CBC.

🤱 Lactation Safety

Contraindicated; excreted in milk.

💊 Overdose Management

Supportive care; monitor for signs of hypervitaminosis A (headache, vomiting, skin peeling).

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🛑 Myths vs. Facts about acitrin 25mg capsule

  • Myth: Generic substitutes of acitrin 25mg capsule are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Acitretin (25mg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of acitrin 25mg capsule can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

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