acicool p 40mg tablet - Uses, Price, Side Effects & Substitutes
Pantoprazole (40mg)
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Medically Reviewed
By SaathiMed Expert Medical Panel
⭐ ZERO POSITION
💊 What is acicool p 40mg tablet used for?
Aciban 40 Tablet (Pantoprazole) is used to treat Gastroesophageal reflux disease (GERD). It contains Pantoprazole (40mg), which Proton pump inhibitor that irreversibly inhibits H+/K+ ATPase in gastric parieta. Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Pantoprazole
Pantoprazole
🏭 Manufacturer
Biologic Psychotropics India Pvt Ltd
Biologic Psychotropics India Pvt Ltd
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category B
Category B
🇮🇳 acicool p 40mg tablet के बारे में संक्षिप्त जानकारी
acicool p 40mg tablet का उपयोग मुख्य रूप से gastro intestinal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Pantoprazole (40mg) मौजूद है।
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.
📋 Complete Drug Information
| Generic Name(s) | Pantoprazole |
|---|---|
| Brand Name | Aciban 40 Tablet |
| Manufacturer | Biologic Psychotropics India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Proton pump inhibitors |
| Route of Administration | Oral |
| Storage | Store at 20-25°C (68-77°F); protect from moisture and light. |
🔬 Pharmacology
Pharmacokinetics
AbsorptionWell absorbed after oral administration; absorption is rapid and complete.
DistributionVolume of distribution about 0.15 L/kg; extensively distributed in tissues.
Protein BindingApproximately 98% bound to plasma proteins, mainly albumin.
MetabolismExtensively metabolized in the liver via CYP2C19 and CYP3A4 isoenzymes.
Half-LifeAbout 1 hour (range 0.5-1.5 hours) in healthy subjects; prolonged in hepatic impairment.
ExcretionPrimarily renal (about 80% as metabolites); remainder in feces.
BioavailabilityOral bioavailability about 77%.
Onset of ActionWithin 1 hour; maximal acid suppression occurs after 2-4 days of dosing.
Peak Plasma Time2-3 hours after oral administration.
Duration of ActionAcid suppression lasts up to 24 hours after a single dose.
Mechanism of Action
Proton pump inhibitor that irreversibly inhibits H+/K+ ATPase in gastric parietal cells.
Step-by-Step Mechanism
1
Pantoprazole is a prodrug that accumulates in the acidic environment of gastric parietal cell canaliculi.
2
It is protonated and converted to its active form, a sulfenamide.
3
The active form binds covalently to cysteine residues of the H+/K+ ATPase enzyme.
4
This binding irreversibly inhibits the proton pump, blocking acid secretion.
5
Acid secretion resumes only after new proton pumps are synthesized.
💡 How to take acicool p 40mg tablet
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at 20-25°C (68-77°F); protect from moisture and light.
⚠️ Side Effects of acicool p 40mg tablet
✅ Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Flatulence
- Constipation
🚨 Serious Side Effects
- Clostridium difficile-associated diarrhea
- Fractures (hip, wrist, spine) with long-term use
- Hypomagnesemia
- Vitamin B12 deficiency
- Acute interstitial nephritis
- Cutaneous lupus erythematosus
⚠️ Rare Side Effects
- Hepatotoxicity
- Pancreatitis
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Agranulocytosis
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Clopidogrel | Major | Reduced antiplatelet effect due to CYP2C19 inhibition |
| Methotrexate | Major | Increased methotrexate toxicity |
| Atazanavir | Major | Reduced atazanavir absorption |
| Rilpivirine | Major | Reduced rilpivirine absorption |
| Cilostazol | Major | Increased cilostazol levels |
| Warfarin | Moderate | Increased INR and bleeding risk |
| Phenytoin | Moderate | Increased phenytoin levels |
| Diazepam | Moderate | Increased diazepam levels |
| Digoxin | Moderate | Possible increased digoxin levels |
| Iron salts | Moderate | Reduced iron absorption |
| Mycophenolate mofetil | Moderate | Reduced mycophenolate absorption |
| Ketoconazole | Minor | Reduced ketoconazole absorption |
| Itraconazole | Minor | Reduced itraconazole absorption |
| Ampicillin esters | Minor | Reduced ampicillin absorption |
| Sucralfate | Minor | Reduced pantoprazole absorption |
🚨 Major Interactions
- Clopidogrel
- Methotrexate
- Atazanavir
- Rilpivirine
- Cilostazol
⚡ Moderate Interactions
- Warfarin
- Phenytoin
- Diazepam
- Digoxin
- Iron salts
- Mycophenolate mofetil
🍽️ Food Interactions
Food may delay absorption but does not affect extent; best taken before meals.
🍷 Alcohol Interaction
No direct interaction; alcohol may aggravate gastric conditions.
🛡️ Safety & Warnings
Pregnancy
Category B
Liver Risk
Low
Kidney Risk
Low
Heart Risk
Low
🚫 Contraindications
Hypersensitivity to pantoprazole or any component; co-administration with rilpivirine.
📊 Monitoring Parameters
Symptoms of acid-related disorders; magnesium levels with prolonged use; bone density with long-term use.
🤱 Lactation Safety
Excreted in breast milk; use with caution.
💊 Overdose
Supportive care; no specific antidote; hemodialysis not effective.
⏰ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.