Aciclowel-P Tablet - Uses, Price, Side Effects, Dosage
What is aciclowel-p tablet used for?
Aciclowel-P Tablet is a combination of Aceclofenac (100mg) and Paracetamol (325mg) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and dental pain. Aceclofenac works by blocking COX enzymes, reducing prostaglandins, while Paracetamol acts on the central nervous system to reduce pain and fever.
- Generic Name: Aceclofenac + Paracetamol
- Manufacturer: Welltrack Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ aciclowel-p tablet Uses & Benefits
Pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, dysmenorrhea, fever.
Off-label uses: Postoperative pain, migraine (limited evidence).
๐ Drug Information
| Generic Name(s) | Aceclofenac + Paracetamol |
| Brand Name | Aldigesic P |
| Manufacturer | Welltrack Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, elevating pain threshold and acting on hypothalamic heat-regulating center.
Mechanism Steps
๐ก How to Take aciclowel-p tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of aciclowel-p tablet
โ Common Side Effects
- Nausea
- Dizziness
- Drowsiness
- Rash
- GI upset
๐จ Serious Side Effects
- GI bleeding
- Hepatotoxicity
- Renal failure
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Anaphylaxis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Aspirin | Moderate | Increased risk of gastrointestinal bleeding |
| Lithium | Moderate | Increased lithium levels |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- SSRIs
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid alcohol.
๐ท Alcohol Interaction
Increased risk of hepatotoxicity (paracetamol) and GI bleeding (aceclofenac).
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, history of asthma with NSAIDs.
๐ Monitoring Parameters
Liver function tests, renal function, CBC, blood pressure.
๐คฑ Lactation Safety
Caution; paracetamol is safe, aceclofenac may be excreted in small amounts.
๐ Overdose Management
Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care for aceclofenac.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose.