Abra-DSR Capsule - Uses, Price, Side Effects
What is abra-dsr capsule used for?
Abra-DSR Capsule is a combination medicine containing Domperidone (30mg) and Rabeprazole (20mg). It is used to treat gastroesophageal reflux disease (GERD), acidity, heartburn, and nausea. Domperidone helps control vomiting by blocking dopamine receptors, while Rabeprazole reduces stomach acid production by inhibiting the proton pump. This dual action provides relief from symptoms and promotes healing of the esophagus.
- Generic Name: Domperidone + Rabeprazole
- Manufacturer: Afive Pharma
- Medicine Form: Allopathy
- Pregnancy Category: A
🇮🇳 abra-dsr capsule के बारे में संक्षिप्त जानकारी (Hindi Summary)
abra-dsr capsule का उपयोग मुख्य रूप से gastro intestinal और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Domperidone (30mg) + Rabeprazole (20mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
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📋 Drug Information
| Generic Name(s) | Domperidone + Rabeprazole |
|---|---|
| Brand Name | Acera-D Capsule SR |
| Manufacturer | Afive Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from light and moisture. |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
📅 When to take abra-dsr capsule?
💡 How and when to take abra-dsr capsule?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at room temperature (20-25°C), protect from light and moisture.
⚙️ How abra-dsr capsule Works
Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Rabeprazole: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion.
💊 abra-dsr capsule Uses in Hindi (Ke Fayde), Benefits & Indications
⚠️ What are the side effects of abra-dsr capsule?
✅ Common Side Effects
- Headache
- Diarrhea
- Constipation
- Abdominal pain
- Nausea
- Dry mouth
🚨 Serious Side Effects
- QT prolongation
- Ventricular arrhythmias
- Torsades de pointes
- Gynecomastia
- Galactorrhea
- Liver injury
⚠️ Rare Side Effects
- Extrapyramidal symptoms
- Hyperprolactinemia
- Interstitial nephritis
- Clostridium difficile infection
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Increased risk of bleeding |
| Ketoconazole | Moderate | Increased domperidone levels |
| Digoxin | Moderate | Increased digoxin levels |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP2C19 inhibitors (e.g., fluconazole)
- QT-prolonging drugs (e.g., amiodarone, moxifloxacin)
⚡ Moderate Interactions
- Antacids
- Sucralfate
- Digoxin
- Methotrexate
ℹ️ Minor Interactions
- Caffeine
- Theophylline
🍽️ Food Interactions
Food may delay absorption of domperidone; rabeprazole absorption unaffected by food.
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity to domperidone or rabeprazole; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concomitant use with QT-prolonging drugs or strong CYP3A4 inhibitors.
📊 Monitoring Parameters
ECG for QT interval; liver function tests; renal function; serum electrolytes.
🤱 Lactation Safety
Domperidone: Excreted in breast milk, may cause adverse effects; Rabeprazole: Excreted in breast milk, use with caution.
💊 Overdose Management
Symptomatic and supportive treatment; gastric lavage; monitoring of ECG for QT prolongation.
⏰ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
🛑 Myths vs. Facts about abra-dsr capsule
- Myth: Generic substitutes of abra-dsr capsule are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Domperidone (30mg) + Rabeprazole (20mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of abra-dsr capsule can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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